Paroxetine (paroxetine)


PAROKSETIN (Paroxetine).
     (2 )(-)-( 3S, 4R) -4 - (para-fluorophenyl) -3-[(3,4 - methylenedioxy) phenoxy] methyl-piperidine.
     Synonym : Paksil, Paxil.
     On mechanism of close to fluoxetin (see) and sertralinu (see).
     Referring to the "balanced" antidepressants dominated anksioliticheskih and sedative properties.
     Completely absorbed from the digestive tract, C max 5 h, T1 / 2 to 21 h; Under intense biotransformation in the liver, allocated mainly to part with urine and faeces.
     Applied to treat depressive disorders.
     There was good preparation panic disorder and obsessive impulsive.
     Assign inwards in the form of tablets. Обычная доза для взрослых 0,02 г (20 мг) 1 раз в сутки (принимают, как правило, утром). If necessary, and good endurance its increase to 0.01 g (10 mg) at intervals of 1 week to a maximum dose of 0.05 g (50 mg) per day (older persons to 0.04 g / day).
     Possible side effects, contraindications and precautions are basically the same as for fluoxetin and sertralina.
     Compatible with MAO inhibitors (be observed 2-week break), increased bleeding, while admission to the proximity effect and anti-alcohol; Inducible mikrosomalnogo oksisleniya (barbiturates, difenin) decrease, and inhibitors (tsimetidin) paroksetina increase concentration in the blood.
     Recommended lower dose drug when applied in combination with other antidepressants, derivative fenotiazina, antiaritmikami I class.
     Be wary appoint persons who potentially hazardous activities that require greater attention and speed of reaction.
     Product : pills to 0.02 g (20 mg) (N. 14, 28).
     Storage : List B.

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