PAMIDRONAT SODIUM (Pamidronate disodium).

     Dinatrievaya salt (3-amino oksipropropiliden) - difosfonovoy acid.

     Synonym : Aredia, Aredia.

     On chemical structure and the mechanism of close to alendronatu sodium.

     It stops bone resorption.

     T? at 27-28 h; biotransfomatsii not be allocated kidneys.

     Assign primarily with osteoporosis (osteolize) in patients with malignant tumors of bone metastasis, as well as the "steroid" osteporoze Pedzheta and disease.

     Îòìå÷åíî, ÷òî ïðè ïðèìåíåíèè ïðåïàðàòà óìåíüøàþòñÿ áîëè â êîñòÿõ è íàáëþäàþòñÿ ïðèçíàêè ðåïàðàöèè â î÷àãàõ îñòåîëèçà.

     Assign a slow Infusion (can not struyno). Dried powder first to throw in the water for injection (0,015 g dissolve in 5 ml; 0.03 g, 10 ml) and then prepare the solution for the infusions. Dose set individually, taking into account the initial concentration of calcium in the blood. For adults and the elderly, with the concentration of calcium in the blood below 3 mmol / l exchange dose of 0,015-0,03 g, and 3-3,5 mmol / l-0,03-0,06 g, and 3 5-4 mmol / l to 0.09 g. The maximum dose rate-0.09 g. total dose designate a single Infusion (within 2 hours) or multiple infusions (within 2-4 days).

     In introducing disease Pedzheta 0.03 grams in a 4-hour Infusion 3 days; Perhaps repetition rate.

     The application is likely to develop drug gipokaltsiemii temperate, moderate hyperthermia, nausea, vomiting, pain in the bones, blood oppression, allergic reactions, pain at the injection.

     Contraindications expressed in violation of kidney function, pregnancy and breastfeeding.

     Incompatible with the infusion solutions containing calcium.

     Product : dried powder for injection solutions in vials of 0,015; 0.03; 0.06 and 0.09 g (15, 30, 60 and 90 mg) together with the solvent.

     Storage : at a temperature no higher than 30 ° C.

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