PAHIKARPIN (Pachycarpinum).

     Pahikarpin - pygmy contained in the plant Daeungjeon tolstoplodnaya (S-op r h on a race hycarpa S. A. M.), herewith. pulses (Leguminosae); also in the T hermopsis R. lanceolata In r. , and other plants.

     In clinical practice using pahikarpina gidroyodid (Ra chicarpini hydroiodidum).

     Synonyms : d-Sparteina gidroyodid, Pachycarpinum hydroiodicum.

     The white crystalline powder bitter taste. Mg in the water (1:30), sterile injectable solutions at the temperature of 100 'C for 30 min; 3% solution of pH 6, 7, 7, 6.

     Pahikarpin is dvutretichnym reason : unlike benzogeksoniya and similar structured products pahikarpin no quaternary nitrogen atoms (onievyh groups "); However pahikarpin like these compounds, has the ability to block vegetative nerve. Pahikarpin a less active, but it is convenient for use inside, as is readily absorbed from the gastrointestinal tract.

     Applied pahikarpin as ganglioblokatora mainly in the peripheral vascular spasm, and ganglionitah. Pahikarpin improves muscle function in myo.

     Assign inside (to food), intramuscularly and subcutaneously. In obliteriruyuschem endarteriite are inside of 0.05-0.1 g 2 - 3 times a day. Treatment for 3 to 6 weeks. After 2 to 3 months treatment with worsening process can be repeated. In ganglionitah designate the interior of 0.05-0.1 g 2 times a day for 10 to 15 days. When myo-appointed interior of 0.1 g 2 times a day for 40 to 50 days. The course of treatment repeat 2 - 3 times in 1 2 - 3 months.

     An important feature is its ability pahikarpina improve tone and strengthen muscles reduce the uterus. Therefore pahikarpin relatively widely used to enhance delivery of weakness in the labor and delivery in early derogation waters, as well as the weakness futile. Diluted unlike pituitrina is raising blood pressure and may be eligible for expectant mothers suffering from hypertensive disease.

     Method of issuance : pills to 0.1 g; 3% solution in 2 ml ampoules.

     Storage : List B. In the dark spot.

     In recent years by the emergence of more effective drugs pahikarpinom for this purpose are relatively rare.

     If pahikarpina incentive for generic activities, he was appointed intramuscularly or subcutaneously for 2 to 4 ml of 3% solution (less interference by 0.1 - 0.15 g per reception); 1 to 2 h product can be introduced again. The impetus to the emerging after 5-30 minutes after pahikarpina. To be most effective, you can assign both inside quinine to 0.2 grams per 30 minutes (only 4 times). In subinvolyutsii uterus in the postpartum period are pahikarpin inside of 0.1 g 2 - 3 times a day.

     Higher doses for adults inside : single 0.2 g, 0.6 g daily; Under the Skin : single 0.15 g (5 ml of 3% solution), the daily 0.45 g (15 mL 3% solution).

     Pahikarpin contraindicated in pregnancy, a violation of the functions of liver and kidney, with strokes and heart disorders expressed.

     Leave the drug should be made only on medical prescription. Admission pahikarpina in high doses not to appoint him (abortion) can cause toxic phenomenon until severe poisoning. First aid with poisoning : washing stomach, artificial respiration, intravenous isotonic solution of sodium chloride or glucose, oxygen inhalation, a cardiovascular funds.

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