OKSITOTSIN (Oxytocinum).

     Oxytocin is a peptide hormone (oktapeptidom) back shares glands. Consists of pentapeptidnogo cycle and the side chain of three amino acid residues. Cycle formed in such a way that two teams tsisteina (in 1 and 6), hinging create disulfidny bridge.

     Currently, synthetic oxytocin get through.

     Synonyms : Sintotsinon, Ipofamin, Ocytocin, Orasthin, Oxystin, Oxytocin, Partocon, Pitocin, Pitupartin, Synpitan, Syntocinon, Utedrin, Uteracon and others.

     The main pharmacological properties oxytocin is the ability to cause severe reduction in uterine muscles, particularly pregnant. This action related to the influence of oxytocin on cell membrane Oxytocics; The direct impact on MMOTP elements mioplazmy he does not have. The effects of oxytocin increased membrane permeability for potassium ions, reduced its capacity and increased anxiety. Oxytocin increases secretion of milk, making a laktogennogo front of pituitary hormone (prolactin). In addition, it can cause rapid allocation (discarding) of breast milk in regard to the impact on its sokratimye elements. According to the uterus of synthetic oxytocin similar to the natural medicines back shares glands (pituitrinom, gifototsinom).

     Because that oxytocin is free of other hormones, it has more electoral act provides only weak Vasopressin effects; Has no effect on AD or more it improves. Since the drug free of protein, peptide and the other side substance, it can be administered intravenously, without the risk of anaphylactic and pirogennogo.

     Applied to produce and promote labor activity. Preparation is the most effective for early derogation amniotic waters. He also appoint the weakness in the labor activity of the uterine atony, and hypotonic uterine krovotecheniyah. It can be used to artificially raise the birth (with complications of pregnancy).

     Enter intravenously or intramuscularly. Intravenous is a fast (in 1 / 2 to 1 min) increased labor; Sluggish battle more severe, in the absence of labor, they usually appear quickly. Intramuscular has a less dramatic effect.

     To initiate the birth impose intramuscularly 0,5-2, ED 0 (= 0.5-2 0 ME) oxytocin : if necessary, repeat injections every 30-60 minutes.

     For intravenous grow 1 ml of synthetic oxytocin (5 ED) in 500 ml of 5% glucose solution and mouth drip from 5 to 8 drops per minute, and then gradually increase the number drops (every 5 to 10 minutes to 5 drops, but no more 40 drops per minute) to a robust labor activity. Drip introduction continue throughout descent act, and the number of input solution can be reduced to a minimum, a good supporting tribal activities. It began with a herbal infusion of oxytocin and analgeziruyuschie means (aprofen, promedol etc.).

     Sharp intravenous oxytocin dose of 0.2 ml (1 ED) in 20 ml of 40% glucose solution is possible only with the full opening of the cervix and the conditions for the rapid settlement of a natural birth.

     To stimulate labor usually do intramuscularly at 0.25 to 1, 0 ED oxytocin.

     Sometimes oxytocin nominated for rodovozbuzhdeniya with prostaglandines (see).

     Oxytocin should be used under medical supervision. Consideration must be given to individual sensitivity to oxytocin. In some cases, even after vvedennya 1 ED may come a sharp battle with the development of intrauterine hypoxia, in total dose can be increased to 4 - 5 ED.

     Oxytocin for stimulation is not suitable for non-delivery of the fetus and pelvis, lateral position and intended fruit, threatening uterine rupture, a scarring of the uterus after delivery sechennya forward earlier.

     Oxytocin also used for the prevention and treatment of hypotonic uterine bleeding. In protracted birth, accompanied by the weakness of labor activity and pererastyazheniem uterus, enter immediately after birth, or his last hand of 3 ED oxytocin intramuscularly or uterine neck. Oxytocin is recommended caesarean sections (3 - 5 ED in the uterine wall after removing the effects).

     To prevent hypotonic uterine bleeding impose intramuscularly for ED-5 3 2 - 3 times a day every day for 2 to 3 days, and if such bleeding-5 - 8 ED 2 - 3 times a day for 3 days.

     If necessary treatment oxytocin (for the prevention and treatment of hypotonic uterine bleeding) can be repeated after 4 - 5-day break.

     Product : in ampoules for 1 or 2 ml containing 5 or 10 ED oxytocin.

     Storage : List B. In cool, the dark spot.

     When using oxytocin syringes must be freed of residual alcohol (Rinse with water for injection).

Materials allowed to copy only with the active hyperlink to the handbook of medicines