OKSODOLIN (Oxodolinum). 1-Okso-3- (3'- sulfamoil-4'- chlorophenyl) -3 - oksiizoindolin.

     Synonyms : Gigroton, Urandil, Chlorphtalidolone, Chlortalidone, Edemdal, Famolin, Hidronal, Higroton, Hygroton, Igroton, Isoren, Natriuran, Oradil, Phthalamidine, Renon, Saluretin, Urandil, Urofinil, Zambesil.

     White or white with a yellowish sheen weak melkokristallichesky powder. Almost nerastvorim in the water, little is soluble in alcohol.

     Oksodolin, as dihlotiazid contains molecules sulfonamidnuyu group. Like dihlotiazidu drug blocks the reabsorption of sodium in the proximal part of distal channel, and is part of proximal Channel. Features of the product is the relative length diureticheskogo effect due to its slow breeding kidneys. Diuretichesky effect begins after 2 to 4 h after administration, and usually lasts more than a day (sometimes on day 3). The drug is effective in some cases in refrakternosti to dihlotiazidu (gipotiazidu).

     Indications for use are the same as for dihlotiazida; Designate drug as not only diureticheskogo but antihypertensive funds.

     The drug is well absorbed by ingestion. Write with urine (about 25%) and faeces (about 75%).

     Inside applied in the form of tablets (usually in the morning before breakfast). Dose picked individually, depending on the severity of the disease and provided effect.

     When taken as a single dose diureticheskogo means varies from 0,025 g (25 mg) to 0.1 g (100 mg). If necessary, reduce the swelling rapidly increasing single doses up to 0.2 g (200 mg), or use a combination of diuretikom providing quick action, such as furosemide (morning - 0.04 - 0.08 g furasemida, but after 6 to 8 h - 0.05-0.1 g oksodolina).

     In achieving the necessary economies of moving to intermittent use of the drug for 0,05 - 0,1 g in 2 - 3 days. Usually treatment 2 to 4 weeks. When hypertension chopped (1 to 3 days) treatment oksodolinom could last many months.

     When hypertension and symptomatic hypertension oksodolin appoint 0,025 0.1 g 1-a-day (morning), are used in conjunction with rezerpinom (0.05 g oksodolina rezerpina and 0.0025 g), b-adrenoblokatorami, apressinom.

     The length of treatment depends on the earnings effect and endurance drug.

     Possible side effects, precautions and contraindications are the same as for dihlotiazida. Oksodolin kaliyuretichesky has several lesser effect than dihlotiazid, but in its application to amend the exchange of potassium.

     Product : pills to 0.05 g (50 mg) in a package of 50 pieces.

     Storage : List B. In a dry, cool, the dark spot.

     Oksadolin is part of pills "Neokristepin (see Reserpine.) .

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