ÎÐÍÈÄ (Ornidum).

     Ortho Brombenzil-N- etildimetilammoniya bromide.

     Similar parameters toluol- acids (or tozilaty) produced abroad under the title : Bretylan, Bretylat, Bretylin, Bretylii tosilas, Bretylium tosilate, Darenthin and others.

     The white crystalline powder and odourless. The easily soluble in water, alcohol. Gigroskopichen.

     Ornid belongs to the group simpatoliticheskih (see Oktadin, Reserpine). However, he has expressed antiaritmicheskoy activity.

     On mechanism simpatoliticheskogo action ornid different from rezerpina and oktadina. Simpatolitichesky effects associated with block allocation from noradrenalina presinapticheskih nerve endings and decrease in connection with the impact on neyromediatora adrenoretseptory. Ornid directly blocking effect on adrenoretseptory not help.

     Ornid mainly used as a means antiaritmicheskogo. He adds refrakterny period, and is particularly effective in measuring ventricular origin.

     To some extent antiaritmichesky effect ornida adrenergicheskogo due to the weakening effect on the heart. It has also been suggested that the action antifibrillyatornogo ornida (and other simpatolitikov) is the blockade of potassium channels cardiomyocytes, resulting in the accumulation of intracellular potassium ions.

     As simpatolitik, ornid lowers AD; Earlier he suggested as a means of antihypertensive. But anti-hypertensive effect he expressed in a moderate way.

     Assign ornid with zheludochkovyh notice : Atrial tahiaritmii, arrythmia (especially blindness to other drugs).

     For cupping the witness or injected intramuscularly at a rate of 0.1 ml of 5% solution (5 mg) for 1 kg of body weight; To prevent departments impose intramuscularly to 0.5 to 1 ml of 5% solution of 2 to 3 times a day.

     In imposing drug may Orthostatic hypotension, as well as general weakness, a feeling of warmth, swelling of the mucous membrane nose, sometimes temporary impairment of the sense of tension and pain in the gastrocnemius muscle.

     Contraindications : severe violations of cerebral circulation, hypotension, expressed renal failure.

     Product : 5% solution of 1 ml ampoules in a package of 10 vials.

     Storage : List B. In the dark spot.

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