Ornidazol (ornidazole)


ORNIDAZOL (Ornidazole).
     ? (Chloroethane) -2 - metil-5- nitroimidazol-1- ethanol.
     Synonyms : Avrazor, Tiberal, Avrazor, Tiberal.
     On chemical structure similar to metronidazole, but in a molecule hloretilnuyu group.
     On spectrum antiprotozoynoy activity ornidazol close to metronidazole and tinidazolu : operating on trichomona, amoeboids, lyamblii, anaerobic bacteria.
     Metronidazole is different than most of the time, and the lack of inhibition effect on the enzyme atsetaldegidrogenazu and therefore does not lead to accumulation of acetaldehyde and sensibilazatsii organism to act alcohol (see Teturam).
     If ingestion is rapidly absorbed, bioavailability of 90%, S-max 3 h, T? 13-h; biotransformation are in the liver, kidneys predominantly displayed.
     Applied for the treatment of trichomoniasis in women and men, as well as amebiaza and Giardiasis. You can designate with anaerobic infections.
     Is inside (after eating).
     In uncomplicated trichomoniasis adults appoint 0.5 g (1 tablet) morning and evening during the five days or 1.5 g once, when compounded by 0.5 g every 12 hours for 10 days; Morning-to 25 mg / 1 kg per day.
     In amoebic dysentery appointed within 3 days : adults weighing up to 60 kilograms and children weighing more than 35 kg-1 x 1.5 g evening; Adults with a body weight of 60 kg for 1 g morning and evening; Children with weighing up to 35 kg, 40 mg / kg one time a day.
     In Giardiasis designate adults and children weighing more than 35 kg to 1.5 g, children weighing up to 35 to 40 mg / kg one time a day (evening) for 5-10 days.
     In anaerobic infection dose for adults - 0.5 g every 12 hours
     In applying the drug may dizziness, headache, peripheral neuropathy, tremor, convulsions, violation of the coordination of movements and other side effects.
     The drug should not be appointed in the first trimester of pregnancy and breastfeeding.
     Product : pills to 0.5 g (N. 6, 10).
     Storage : List B.

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