ORTSIPRENALINA SULFAT (Orciprenalini sulfas) *. 1-(3, 5-Dioksifenil) -2 - (izopropilamino) - 1-ethanol sulfate.

     Synonyms : Alupent, Astmopent, Alotec, Alupent, Astor, Dosalupent, Metaproterenolsulfat, Novasmasol, Orciprenaline sulfate.

     On chemical structure and pharmacological properties similar to izadrinu (base ortsiprenalina different from izadrina location hydroxyl groups in the benzene nuclei).

     The drug is a stimulant b-adrenoreceptor mixed operating on 1-b and b-2 adrenoretseptory, but compared to izadrinom a more selective in their b-2 adrenoretseptory bronchi than the heart, to a lesser extent, a matter of tachycardia and lower blood pressure. Provides longer bronhorasshiryayuschee effect than izadrin. After inhalation ortsiprenalina (alupenta, astmopenta) is caused by 10 to 15 minutes, reaching a peak in 1 hour and lasts until 4 - 5 hours

     Key testimony to the application of the same as for izadrina : bronchial asthma, chronic asthmatic bronchitis, pnevmoskleroz, emphysema lungs, as well as violations atrioventrikulyarnoy conductivity.

     Applied ortsiprenalin by inhalation and parenteral.

     For edema and prevent asthma attacks using a special spray pump, when you click on the valve that sprayed a constant dose of the drug, equal to 0.75 mg. Usually a one ingalyatsin; If necessary, do after 5 min second inhalation. Before clicking on the pump valve displace Above bottom.

     For cupping the asthma drug can also write subcutaneously or intramuscularly : adult for the 0.5-1 mg (1 - 2 mL 0.05% solution), sometimes intravenously : 1 ml of 0.05% solution (0.5 mg ) enter slowly (within 3 min).

     With long-term therapy for the prevention of asthma attacks ortsiprenalin nominated in the form of tablets (to 0.02 grams pill) : adults and 1 / 2 - 1 3 - 4 pill twice a day; Children under 1 / 4 -1 / 2 tablets 2 4 times a day. The effect when administered is usually in 1 hour and lasts 4 to 6 hours

     In atrioventrikulyarnoy blockade drug use with caution, introducing slow intravenous 0.5 to 1 ml 0.05% solution, or intramuscularly or subcutaneously 1 to 2 ml; If necessary, impose by slow intravenous drug Infusion.

     For Infusion content to throw one-two vials of 10 ml of 0.05% solution (5 to 10 mg) in 250 ml of 5% glucose solution and isotonic sodium chloride solution and impose a speed of 10 to 20 drops per minute.

     To prevent attacks with Stokes-Adams syndrome, Morgani, with absolute bradiaritmii and drug intoxication lapidary appointed interior and 1 / 2 - 1 tablet (adult) 6 to 10 times a day, changing the dose and frequency techniques depending on the rhythm of the heart.

     Ortsiprenalin usually best transferred than izadrin, but when applied possible side effects, such as when applying izadrina (see). When intravenously may reduce blood pressure.

     Method of issuance : the aerosol inhalers containing 400 single dose (0.75 mg of) preparation; 0.05% solution in ampoules of 1 and 10 ml (0.5 and 5 mg); Pills to 0.02 g.

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines