ONDANSETRON (Ondansetron).

     4 H Karbazol-4- he tetragidro-9- methyl 1,2,3,9-[(2-methyl-1 H imidazol-1- mud) methyl].

     Available in a monogidrohlorida.

     Synonyms : Zofran, Latran, Ondazan, Osetron, Emeset, Emetron, Emeset, Latran, Ondansetron, Ondasan, Osetron, Zofran.

     White or almost crystalline powder. Mg in the water.

     Has protivorvotnoe effect because of the blocking peripheral and central serotonin (5-NT3) receptors (see Serotonin).

     If ingestion is well absorbed, bioavailability of about 56%, S-max with intravenous and oral application, 10 minutes and 1.7 hours, T 1 / 2 3,0-5,5-h; Biotransformation are in the liver, kidneys displayed mostly as metabolites.

     Applied with vomiting associated with chemotherapy or radiation therapy of malignant neoplasms in the aftercare period. Warn or eliminate vomiting.

     Assign intravenously, intramuscularly, inside and rectally.

     In temperate emetogennoy chemotherapy and radiation therapy to introduce 0,008 g (8 mg) intravenously prior to the course, inside or outside? -2 H prior to the course and after 8-12 h after the course, or 0,016 grams (16 mg) rectally for 1-2 h before the course or infuzionno 0,032 g (32 mg) for 15 minutes to 30 minutes before the course, or 0.15 mg / kg 3 times for 30 minutes before and then through 4 8 h after the course.

     For the prevention of nausea and vomiting later imposed on the inside of 0,008 g, 2 times a day or rectally 0,016 g (16 mg), 1 per day for 1-2 days (up to 3-5 days) after completing chemotherapy.

     Doses of the drug choose individually depending on the effect and endurance.

     Children give vein at 5 mg / square. M surface of the body; To prevent vomiting designate tablets of 0,004 grams (4 mg) two times a day.

     In applying the drug may headache, diarrhoea or constipation, dry mouth, Hiccup, liver failure, a breach of accommodation, parestezii, extrapiramidale disorder, arterial hypotension, arrhythmia, bronchospasm, allergic skin reactions.

     Contraindications : liver failure; I trimester of pregnancy, breast-feeding.

     Method of issuance : pills for 0,004 and 0,008 grams (4 and 8 mg) (N 10); Rektalnye jobs for 0,004; 0,008 and 0,016 grams (4, 8 and 16 mg); 0 , 08% syrup in vials of 50 ml; 0.2% solution in ampoules of 2 and 4 ml.

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines