OMEPRAZOL (Omeprazole) *. 5-Methoxy [[(4-metoksi-3, 5 - dimethyl-2-piridil) methyl] sulfinil] benzimidazol.

     Synonyms : Losec, Omeprol.

     On chemical structure has some similarities with tsimetidinom but still influence N2- receptors have not. However, it is a very effective tool for antiulcer. Diluted lipofilen very easily penetrate parietalnye gastric mucosal cells, concentrated in and provided tsitoprotektornoe effect; Protects the mucous membrane of the stomach and duodenal ulcers. I think that protivoyazvennoe of omeprazola primarily due to the embargo "acid pump, reducing gastric acid secretions, which is linked to the braking Na +-K +-ATFazy in parietalnyh cell membranes.

     Applied treated seriously when leaking chronic ulcer is not curable antiulcer other means, with erosive reflyuks- ezofagite with Zollinger-Ellison syndrome.

     Assign inside. Regular doses of gastric ulcer 20 1 mg once a day (or 40 mg / day); Peptic ulcer and bowel erosive reflyuksezofagite to 20 mg per day; With Zollinger-Ellison syndrome from 20 to 60 mg or more (up to 120 mg) in day (2 admission). The course of treatment lasts, on average, four weeks.

     In applying omeprazola possible diarrhoeal phenomenon and other side effects. Diluted aggravating kumarinov and difenina slows for benzodiazepines (diazepam, or sibazona).

     Contraindications : pregnancy and breast-feeding.

     Product : capsules, containing 0.02 g (20 mg) omeprazola pellets.

     Storage : List B.

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