OLIVOMITSIN (Olivomycinum).

     Is Antibiotic substance produced radiant fungus Actinomyces olivoreticuli.

     Applied as sodium salt, a powder or porous mass of yellow to greenish tint. The easily soluble in water, isotonic sodium chloride solution, solutions novocaine.

     The drug has antitumor activity. Mechanism of action associated with selective suppression of DNA synthesis dependent RNA.

     Applied intravenously. Intramuscularly and subcutaneously not enter because of the potential infiltrates and necrotic tissue. When ingestion poorly absorbed.

     Intravenous olivomitsin used in testis tumors (seminomy, embryonic crab, teratoblastomy) under Generalization (with metastasis), if tonzillyarnyh tumors (limfoepiteliomy, retikulosarkomy etc.), with the defeat retikulosarkomah peripheral nodes with horionepiteliome uterus, and cervix cancer.

     Enter intravenously to adults, beginning with 5 mg dose (0,005 grams). If the patient is well experienced first introduction to increase the dose to 10 mg, and then gradually to 15 mg / introduction (approximately 0.25 mg / kg). Enter slowly (over 2 to 3 minutes) drip. Repeat injections every 48 hours. Total on-course (10-20 introductions) is 150-300 mg (0.15 - 0.3 g) olivomitsina.

     Under favourable results, the treatment can be repeated after 1 - 1, 5 months.

     Children entering from the dose of 0.1 mg (0.0001 grams) per 1 kg of body weight. Gradually increase the dose to 0.2 - 0.25 mg / kg; In the course of treatment using 2 - 5 mg / kg.

     Solutions sodium salt olivomitsina prepared immediately before injection, stretched content bottle (0.02 g product) in the 10 - 15 ml of sterile isotonic sodium chloride solution.

     Olivomitsin may be nominated in combination therapy with other drugs and radiation therapy, in cases when the use of other drugs is not possible, in conjunction with radiation and thrombocytopenia, as well as the sustainability of tumors to alkiliruyuschim connections, and radiation treatment.

     In applying olivomitsina may be nausea, vomiting, increase body temperature. In order to prevent these side effects to give to a drug, dimedrol (or other protivogistaminny product), and after-aminazin (25 mg inside).

     In the case of the fungal disease mucous membranes (mouth) designate nystatin (ED 500000 to 2 times daily) or caramel dekamina (see).

     When expressed diarrhoeal events (hard nausea, vomiting, loss of appetite or demotion) reduce or increase the dose interval between the introduction to 72 hours

     During treatment olivomitsinom need to monitor the cardiovascular system and blood picture.

     In connection with a possible kardiotoksichnostyu, preparation is not suitable for serious diseases, cardiovascular system, as well as a sharp depletion of the patient in terminal stages of cancer.

     Product : in the hermetically ukuporennyh bottles containing 0.02 g (20 mg), sodium salt olivomitsina.

     Storage : List A. dry, the dark place at a temperature no higher than 20 C.

Materials allowed to copy only with the active hyperlink to the handbook of medicines