Oktreotid (octreotide)


OKTREOTID (Octreotide).
     Synonym : Sandostatin, Sandostatin, Somatostatinum.
     Synthetic peptides (oktapeptid), close to the structure and operation of natural somatostatin (endogenous), but is much more stable and lasting action.
     Oktreotid with subcutaneous injections rapidly absorbed; The maximum concentration in plasma is achieved within 30 min; When intravenously out in two phases with half-time 10 and 90 minutes.
     Applied oktreotid (sandostatin) to reduce the concentration of growth hormone in akromegaliii, including in cases of inefficiency agonists release (see Bromokpiptin); To address the symptoms svyazannyhs endocrine pancreatic tumors gatro- enterovirus system; To prevent complications after operations podzhenludochnoy iron ; when profuznoy secretion diarrhea and reflexive diarrhea associated with AIDS, dumping syndrome, Astrom pancreatitis.
     Assign usually subcutaneously. In akromegalii imposed on 0,05-0,1 mg (50-100 µ g) with intervals 8 or 12 hours Dose make the determination of the concentration of growth hormone, clinical symptoms, portability. Usually the best daily dose is 0.3 mg. Maximum ustochnaya 1.5-mg dose.
     In endocrine pancreatic tumors gatro- enterovirus type system to 0.05 mg (50 µ g) 1-2 times Deni, with a gradual increase (if necessary) up to 3 times a day.
     When diarrhea imposed on 0,1-0,2 mg 2-3 times a day over a period of 5-7 days.
     In refraktornoy diarrhea associated with AIDS, to be 0,1-0,2 mg three times a day (if necessary, and more than 0.3 mg three times a day).
     To prevent complications after surgery on the pancreas vvodyat to 0.1 mg three times a day for seven days, starting 1 hour before the operation.
     Daily intake should normally not exceed 0.75 mg (750 µ g) for adults.
     Children vvodyat per 0,001-0,01 mg (1-10 µ g) per 1 kg of body weight.
     Intradermal injections painful preparation.
     In some cases, resorted to with intravenous.
     Oktreotid be applied under close medical supervision in a laboratory.
     The local side effects include pain, itching, burning at the injection.
     Can nabdyudatsya anorexia, nausea, vomiting, abdominal pain, diarrhea, steatoreya.
     Possible violations of tolerance to glucose and liver function, the emergence of biliary tract stones (in long-term use drugs).
     Sometimes pituitary tumors can grow, produce somatotropin.
     When pregnancy and during lactation use sandostatina possible only by absolute grounds.
     Product : injection of capsules containing 0.05; 0.1 or 0.5 mg (50; 100 or 500 µ g) in 1 ml; Reusable bottles containing 1 mg (1000 µ g) in 5 mL solvent .
     Storage : at temperatures from 2 to 8 C (up to 2 weeks at room temperature).

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