NIMUSTIN (Numustine).

     3-[(4-Amino-2- metil-5- pirimidinil) -2-methyl] -1 - (2-chloroethyl) -1 - nitrozomochevina.

     Synonym : Nidran, Nidran.

     Powder. Well soluble in water.

     On the chemical structure and tsitostaticheskomu of close to lomustinu and karmustinu.

     Applied in malignant tumors of the brain, lungs, digestive tract, with malignant lymphoma, chronic leukemia.

     Enter intravenously at 2 mg / kg 1 every 5-6 weeks or 1 mg / kg in 1 st and 8 th days every 5-6 weeks. Solutions are ex tempore of the water injection rate of 0,005 grams (5 mg) in 1 ml.

     Possible side effects : blood oppression, diarrhoeal phenomenon, headache, convulsions, hemorrhagic symptoms, fever, Alopecia, rashes, seldom-interstitial pneumonia.

     Contraindications : oppression blood, pregnancy, breast-feeding.

     Product : liofilizirovany powder for injection solutions in bottles of 0.05 g (50 mg).

     Storage : List B.

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