Novokainamid (novocainamidum)

	Novokainamid (novocainamidum) NOVOKAINAMID (Novocainamidum). b-Dietilaminoetilamida para-amino benzoic acid hydrochloride. C inonimy : Prokainamid, Amidoprocain, Cardiorytmin, Novocamid, Pcocainamidi hydrochloridum, Procainamidi hydrochloride, Procainamidum, Procadyl, Procainamide, Pronestyl, etc. White or white with yellow or white crystalline powder kremovatym. Very easily soluble in water, easy-to alcohol. Aqueous solutions colourless, transparent; Metabisulfitom stabilized sodium (0.5%); By 10% solution of 3, 8, 5, 0. Sterile with 100 'C for 30 min. On chemical structure similar to novocaine (see); Instead of broadcasting groups of novocaine (-O-CO) contains amidnuyu group (-S-N-N). On pharmacologically also is similar to novocaine and supplies shall mestnoanesteziruyuschee effect. However, the most important feature novokainamida pharmacologists space is the ability to lower vozbu strength and conductivity of cardiac muscle and inhibit impulses in education Cumulative pockets automatic; In this regard, it is close to quinidine. Referring to the complications I medication group. Applied with various heart rhythm disorders : mertsatelnoy epileptic adults or fibrillation predserdy, paroxysmal tachycardia zheludoch skills, ventricular arrythmia; With operations on the heart, major vessels and light it is used for prevention and treatment of cardiac rhythm Housing races. Diluted appointed interior, intramuscularly or intravenously. When ingestion, it is rapidly absorbed. Peak plasma concentration is 1 to 2 h after administration. Duration about 3 to 4 hours Provided mainly kidneys. In ventricular arrythmia appointed interior first dose of 0.25 g of 0,5-1 (student), followed by 0.25 - 0.5 grams every 4 to 6 hours If necessary daily dose can be increased to 3 g (sometimes up to 4 grams). The length of treatment depends on the effectiveness and acceptability of the preceding Parata. For edema paroxysmal ventricular tachycardia may impose Parat in veins dose of 0.2 - 0.5 g (1 g rarely) at speeds of 25-50 mg / min or are "load" dose of 10 to 12 mg / kg (over 40 - 60 ��), � �� 2 - 3 �� . After cupping hysteria designate supportive dose of inside - 0.25 0.5 grams every 4 to 6 hours When epileptic mertsatelnoy witness initially recommended dose inside the 1, 25 g ( "load"). If the dose is ineffective, then an hour later give more 0,75 g continue every 2 h to 0.5 to 1 g to edema hysteria; The total daily dose of 3 g (sometimes 4 g). You can also designate novokainamid intramuscular injection of 10 ml of 5 - 10% solution (up to 20 - 30 ml / day). If necessary preparation to enter intramuscularly in one dose, 0.5 g (5 - 10% 10 ml solution), and then at intervals 6 h introducing vein (slowly) on the 0.2 - 0.5 g (1 g rarely) or �� 10 - 20 ��/�� 40 -60 �� 2 - 3 �� . When intravenous solution novokainamida grow in 5% glucose races creators or isotonic sodium chloride solution. Bring speed should not exceed 50 mg per minute. That would keep the pulse, AD and EKG. With the rapid development of a possible collapse, vnutriserdechnoy blockade asistolii. When events collapse usually do mezaton (or Levophed); However, it should be borne in mind that older people, especially patients suffering from arterial hypertension, inside a vein mezatona could cause a sharp increase in AD undesirable consequences. Higher doses for adults inside : single 1 g, 4 g daily; Intramuscularly and veins (drip) : single 1 g (10 mL 10% solution), 3 g daily (30 ml 10% solution). In applying novokainamida could experience side effects. In addition kollaptoidnoy reaction to a possible intravenously, may occur (in all ways a) general weakness, headache, nausea, vomiting, stir, insomnia. In the mouth can be a sense of bitterness. In case of overdose and high sensitivity can develop oppression heart fibrillation and Poly, and in long-term use-volchanochny syndrome. In connection with the possible suppression of uterine attacks and the downgrading of AD, caution should be exercised when appoint novokainamid heart attack. In heart failure and shock kardiogennom novokainamida reduced dose (1 / 3 or more). In sharply ser dechnoy failure and sudden changes in vascular sclerosis new kainamid not recommended. The drug is not appointed in zheludochkovyh Arit miyah caused by intoxication cardiac glycosides. If the kidney function is possible synergies. Contraindications : increased individual sensitivity to it; Allergy to novocaine. If possible, prior to the start of a new treatment course kainamidom check reaction to a single patient reception accorded Parata (0.25 -0.5 g inside). Method of production : tablets of 0.25 and 0.5 g of orange glass tubes; 10% solution in sealed bottles of 10 ml and 10% solution of 5 ml ampoules. Storage : List B. In the dark spot. R p. : Ta b. Novo sa inamidi 0.25 N.20 D.S. On June 1 pill once a day R p. : Sol. Novo sa inamidi 5 ml 10% S. At 5 ml intramuscularly R p. : Sol. Novocainamidi 5 ml 10% D.S. Add 15 ml of 5% glucose solution and isotonic sodium chloride solution; Enter veins to 2 ml of 1 min; Drip Infusion assigned to the large number of the same solvent
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