NONAHLAZIN (Nonachlazinum). Hlor-10- 2 - (3-[1, 4-diazabitsiklo- (4, 3, 0) - nonanil-4] - propionil) fenotiazina digidrohlorid.

     White with cream white crystalline powder. Mg in the water, very little of alcohol; PH 1, 5% solution of 2, 3, 2, 8.

     On chemical structure of the derivatives propionilnym fenotiazina (Longtime nonahlazinu to structure and preparation of koronarorasshiryayuschy hloratsizin excluded from the range of medicines as maloaktnvny.) (See also Etmozin, Etatsizin); In a side chain azotsoderzhaschuyu bitsiklicheskuyu system. Unlike aminazina and ftoratsizina no neurotic or antidepressant action.

     Nonahlazin improves blood circulation in the heart by increasing coronary blood flow. The drug increases the oxygen reserve attack. It sokratitelnaya ability to attack increases without significant changes cardiac ejection and heart.

     Mechanism of action nonahlazina poorly understood. It played a role adrenostimuliruyuschie properties (see also Oksifedrin).

     Applied with IBS (with strokes voltage and tranquillity, as well as strokes in the face forward or acute myocardial infarction). To prevent strokes are inside in the form of tablets or solution, and cupping the only form of solution. When administered in solution nonahlazin rapidly absorbed.

     For cupping the nonahlazin used in patients not perenosyaschih nitroglycerin or contraindications to its use. Nonahlazin in solution, unlike nitroglycerin, not lowers AD and is dizziness, but often smoke more effectively eliminates attack than nonahlazin.

     For a course of treatment of chronic IBS designate tablets of 0.03 g (1 tablet) for 1 hour before eating 3 - 4 times a day. Daily intake can be increased to 0.18 - 0.24 g. The course of treatment lasts, on average, 3 to 4 weeks. For 3 - 4 days before the end of the treatment dose is gradually reduced.

     In predynfarktnom able to begin treatment with a reception inside to 5 ml (1 teaspoonful) 1, 5% solution of 3 times a day (with equal intervals) for 3 days, then move on to receive tablets (1 pill 4 to 8 times during the day 3 - 4 weeks). Solution nonahlazina take shock, not squeezed water or other liquids. You can also apply the pill nonahlazina of language, pre razzhevav them.

     For cupping the strokes taken inside for 5 to 10 ml (1 - 2 tea spoons) 1, 5% solution. If necessary, repeat the admission of the drug, with an 4 - 5 hours, not exceeding the total daily dose of the PC Jr. If the attack occurred earlier than 4 h after administration nonahlazina, nausea attack should nitroglycerin.

     If stroke strokes unable nausea nonahlazinom should go to the other Antianginal drugs.

     In high doses, can cause reduced nonahlazin AD and headache.

     Contraindications : expressed as a violation of liver and kidney; It can not be used in conjunction with "adrenoblokatorami. In the process of treatment needs to be taken AD (especially in patients prone to crises PNDS); With increasing pressure to reduce the dose or stop receiving the drug.

     Method of production : tablets of 0.03 g-coated blue, in a package of 20,50 or 100 pieces; 1, 5% solution (colourless transparent liquid) and 25 ml of orange glass bottles (for the reception inside).

     Storage : List B. pills in a dry, the dark places; Solution in the dark field with 5 +-8 'S.

     R p. : Ta b. N of chl a and n zini obd. 0.03

     N.100

     D.S. At one tablet 3 to 6 times a day (for 1 hour before meals)

     R p. : Sol. Nonachlazini 1, 5 ml 25%

     D.S. On May 3 ml per day (PCP inside)

  `Close to nonahlazinu in structure and action Coronaro widening drug hloratsizin excluded from the range of medicines as maloaktnvny. `Close to nonahlazinu in structure and action Coronaro widening drug hloratsizin excluded from the range of medicines as maloaktnvny.

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