NITROSORBID (Nitrosorbidum). 1, 4, 3, 6-Diangidro-D- fluids dinitrate.

     C inonimy : Izoket, Izodinit, Kornilat, Lomilan, Armadan, Carvanil, Carvasin, Cornilat, Corodil, Coronex, Difutrat, Isodinit, Isodril, Isoket, Isonit, Isorbid, Isosorbide dinitrate, Isosorbidi dinitras, Isotrate, Lomilan, Metronitron, Nitrsosid, Rigedal, Risordan, Sorbangil, Sorbidilat, Vascardyn, Vasodilat, Vasorbate and others.

     White melkokristallichesky powder. Almost nerastvorim water, it is difficult to alcohol.

     Nitrosorbid a major antianginalnyh organic nitrates for oral delivery. In a special dosage forms produced sublingual, intravenous and inhalation use.

     When administered in the form of tablets beginning of Nitrosorbid been through 30-50 min, the maximal effect through 1 5 2 h, the total length of 4 to 6 hours or more.

     Nitrosorbid widely nominated as antianginalnogo means for chronic IBS course to prevent attacks; With infrequent attacks stable stenocardia voltage. Make a meal usually 0,005 - 0,01 g (5 - 10 mg), 3 to 4 times a day. Sometimes patients need higher doses of time (20 -30 mg) (For existing data, in order to avoid the development of tolerance to take Nitrosorbid to 30 mg, 2 times a day : 8 am and 13 h, in hours, "the overlying "the greatest physical activity. With 13 hours a day to 8 hours the next morning restored sensitivity to the drug.) .

     Applied sublingvalno (in the form of conventional tablets) Nitrosorbid may nausea stroke, but slower than nitroglycerin (after 3 to 5 minutes).

     In recent years Nitrosorbid, like nitroglycerin, has been made into a peripheral vazodilatatora with heavy forms heart failure. By lowering the tone peripheral venous vascular (venul) product reduces venous blood flow to the heart, pressure vessels in the small circle distress, asphyxia, cyanosis. Is it inside of 20 mg (2 tablets) every 4 to 5 hours

     Sometimes when appointed endarteriite and other diseases involving peripheral vascular spasm.

     Possible side effects : headache, dizziness, nausea are smaller doses.

     Indications are the same as for nitroglycerin.

     With long-term use Nitrosorbid can develop tolerance, and therefore recommended after 3 to 6 weeks regular admission tablets to break a 3 - 5 days, replacing the time Nitrosorbid antianginalnymi other drugs.

     Product : pills to 0,005; 0.01 and 0.02 g (5, 10 and 20 mg).

     Storage : List B. In a dry, cool, the dark place away from the fire.

     Izodinit (Bulgaria) issued in the form of tablets : reception inside (10 mg); Sublingvalnyh tablets (2, 5 mg isosorbide dinitrate in the pill), chewing tablets (10 mg pill in) izodinit ointment and tablets (20 mg in pill), and 0.1% solution for injection in vials of 10 ml (10 mg).

     In addition, overseas drugs produced aerosol form Nitrosorbid "Izomak- spray (Isomac-spray) and others - for cupping the strokes and intravenous dosage forms (Estimated) application (Izodinit for infusions, Bulgaria) and others Izodinit for infusions includes 1 ml 0,001 g (1 mg) isosorbide dinitrate.

     Applied levozheludochkovoy with acute congestive heart failure and elevated pulmonary artery pressure, swelling of the lungs, heavy strokes (see Nitroglitserin - intravenous application).

     Enter in the vein slowly (at the rate of 1 to 10 mg in 1 hour); 0.5 to 1 mL of solution ampulnogo to throw in the 10-20 ml isotonic sodium chloride solution.

     The maximum daily dose of 100-120 mg.

     Product : 0.1% solution in ampoules and 10 ml (10 mg).

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