NIFEDIPIN (Nifedipine) *. 2, 6-Dimetil-4- (2'- nitrophenyl) - 1, 4-digidropiridin- 'W, 5 dikarbonovoy acid dimethyl ether.

     Synonyms : Adalat, Kordafen, Kordipin, Korinfar, Nifangin, Nifekard, Adalat, Adarat, Calcigard, Cordafen, Cordipin, Corinfar, Nifangin, Nifacard, Nifelat, Procardia and others.

     Relevant domestic product-fenigidin (R henyhydinum; R henigidin, henihidin R). The yellow crystalline powder. Almost nerastvorim in water, soluble in alcohol difficult.

     Nifedipine (fenigidin) is the main representative of calcium antagonists ions derived from 1 - 4 digidropiridina.

     Like other antagonists verapamil and calcium ions Nifedipine increases coronary and peripheral (mainly arterial) receptacles inotropnoe has a negative effect, reduces the need for oxygen in the attack. Unlike verapamil has not had a dampening effect on the wire system has a weak heart and antiaritmicheskoy activity. Compared with verapamil stronger reduces peripheral vascular resistance and significantly reduces AD.

     The drug is rapidly absorbed by ingestion. The maximum concentration in plasma is observed in 1 / 2 to 1 hour after administration. There is a short period of half-2 - 4 hours About 80% of kidney appears inactive metabolites, some 15% of faeces. It is proved that prolonged admission (2 to 3 months) develops tolerance (unlike verapamil) to step preparation.

     Applied Nifedipine (fenigidin) as a means antianginalnogo with IBS with attacks strokes, AD for reducing hypertension in various types, including renal hypertension. There are indications that Nifedipine (and verapamil) in nefrogennoy hypertension slows the progression of renal failure.

     Applied also in the treatment of chronic heart failure. Previously thought that Nifedipine and other ions of calcium antagonists are not shown in heart failure because of the negative effect inotropnogo. Recently found that all these drugs because of the peripheral vazodilatatornomu improve heart function and reduce its size with chronic heart failure. There is also a decrease in pulmonary artery pressure. However, we should not exclude the possibility of adverse inotropnogo nifedipina, to be careful when expressed heart failure. Most recently, there have been reports of inappropriate use nifedipina with hypertension, the increase in the risk of myocardial infarction, as well as the possibility of increasing the risk of death in patients with coronary heart disease with long-term use idenfata.

     For this is the "normal" nifedipina (short-acting), but his prolonged dosage forms and digidropiridinov long (for example, amlodipina). The question, however, remains debatable.

     There is a positive impact on the brain nifedipina hemodinamics, its effectiveness in disease Reynaud. For patients with bronchial asthma significant bronhorasshiryayuschego no action, but medication can be used in conjunction with other tools bronhorasshiryayuschimi (simpatomimetikami) for maintenance therapy.

     Is Nifedipine (fenigidin) inside (regardless of meal times) of 0,01 - 0,03 g (10-30 mg), 3 to 4 times a day (up to 120 mg / day). The duration of treatment 1 - 2 months or more.

     For edema gipertonichsskogo Stroke (sometimes with strokes) sublingvalno drug use. Pill (10 mg) were detained language. To accelerate the effect pill fenigidina razzhevyvayut and keep not proglatyvaya by language. In this way, patients in a 30-60 minutes should be the lie. If necessary, after 20 to 30 minutes of preparation repeat admission; Sometimes increasing the dose to 20 - 30 mg. After cupping the switch to oral application.

     Recent findings suggest sublingvalnoe nifedipina inappropriate use, the increase in the risk of side effects of, with the rapid increase "peak" of the drug in the blood.

     Fenigidin (Nifedipine) is usually well tolerated. However, the relatively frequent Blush face and upper torso skin, headache, probably related to the reduction of cerebral vascular tone brain (mainly storage) and tensile by increasing blood flow to arteriovenoznym anastomosis. In these cases, reduce the dose or take medication after eating.

     There also palpitation, nausea, dizziness, swelling of the lower limbs, hypotension, drowsiness.

     Contraindications : severe congestive heart failure and weakness syndrome sinusnogo hub expressed arterial hypotension. In moderate hypotension designate drug in small doses (0.01 g three times a day) under mandatory supervision AD.

     Nifedipine (fenigidin) is contraindicated in pregnancy and breastfeeding.

     Caution is needed in the appointment of drug transport drivers and those of other professions that require rapid mental and physical reactions.

     Product : tablets, coated yellow, containing 0.01 g (10 mg) drug, in a package of 40 pieces; Korinfar, kordafen, nifekard-50 pieces.

     Storage : List B. In the dark spot.

     Nifekard ointment (Nif card retard e) contains one tablet 20 mg nifedipina.

     Product : tablets in a package for PC cards.

     Recently released overseas injection form nifedipina (adalit) capsules in 50 ml (5 mg drug in 18% ethanol solution). Enter in the vein first 1 mg (bolyus), and then at a rate of 1 mg per hour or 17 µ g / min.

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