NITSERGOLIN (Nicergoline). 1, 6-Dimetil-8-b (5-bromo nikotinoil- oksimetil) -10-a metoksiergolin.

     Synonyms : Nikotergolin, Sermion (Sermionum) Dasovas, Dospan, Ergotop, Fisilax, Nargoline, Nicotergoline, Nimergoline, Sinscleron, Varsan and others.

     White or white to slightly yellowish sheen crystalline powder, almost nerastvorim in water, soluble in alcohol.

     On chemical structure is similar alkaloids LPV containing, in addition ergolinovogo kernel bromzameschenny balance nicotinic acid (see).

     Like digidrirovannym derived alkaloids LPV (see Digidroergotamin etc.), provides a nitsergolin - adrenoblokiruyuschee effect. In addition, he has spasmolytic activity, particularly as expressed in the brain and peripheral vascular vessels, which to some extent can be attributed to the presence of molecules in its balance of nicotinic acid.

     Testimony to use nitsergolina are acute and chronic cerebral vascular disorders, especially in the early violations of cerebral circulation (including cerebral arteriosclerosis, cerebral vascular thrombosis effects, etc.), with migraines, vertigo (see also Flunarizin), disorder of peripheral krovoobraschsheniya ( arteriopatii limbs, the disease Reyna, etc.), and diabetic retinopathy, heart failure visual nerve, dystrophic diseases of the eye cornea.

     Is nitsergolin (sermion) inside of food in the form of tablets of 0.01 g (10 mg) three times a day. Treatment for a long-term (2 to 3 months or more, depending on the severity of disease, treatment effectiveness and transferability). Effect develops gradually.

     Possible side effects : hypotension, dizziness, gastrointestinal disorders, mood or, conversely, sleep disorders and skin-reddening face and the upper half of the body, the skin itch (see nicotinic acid).

     When expressed adverse events reduce the dose or stop receiving the drug. When expressed hypotension should take a sleeping position.

     Product : pills to 0.01 g (10 mg).

     Storage : List B. In the dark spot.

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