NIBENTAN (Nibentanum).

     (±) N [5 - (Dietilamino) -1 - fenilpentil] -4 - nitrobenzamida hydrochloride.

     The white crystalline powder. Mg in the water.

     Original antiaritmichesky domestic product class III. Selectively lengthens potential action reduces the amplitude of potassium currents slow straightening cardiomyocytes.

     Intravenous drug introduction to increase the effective period refrakternogo predserdy, Poly and beam Kent, functional refrakternogo period atrioventrikulyarnogo objects, the system Gisa- Purkinje and Poly, as well as other Electrophysiology and clinical changes which characterized antiaritmikov class III (an EKG to drill additional U the possibility aritmogennyh effects, etc.).

     Using EMS for edema in patients with epileptic supraventrikulyarnoy and paroxysmal tachycardia and permanent forms of scintillation and flicker predserdy (except in cases of acute myocardial infarction, as a study of the efficacy of the drug in this category of patients has been undertaken).

     Application nibentana in the House under intensive monitoring EKG monitor control (for 12-24 h). Immediately before each solution of the drug (bolyusa) requires registration ECG in 12 opening, and then dynamically monitor the effectiveness and possible development aritmogennogo effect and timely correction.

     Patients with paroksizmalnymi forms supraventrikulyarnoy keep nibentan injected initially at the rate of 0,125 mg per 1 kg of body weight, razvedya necessary dose of 20 ml isotonic sodium chloride solution. Solution to introduce within the next 3-5 min. In ineffectiveness of the dose in 15 minutes to enter a drug solution to the same dose (0,125 mg / kg).

     When a permanent form scintillation and flicker predserdy give dose of 0,125 mg / kg in one bolyusa. In the first failure of the second possible, and in some cases a third in the same dose at intervals of 15-20 minutes.

     Introduction stop drug rehabilitation after sinusovogo rhythm or develop serious side effects, as well as an increase in the QTc interval of ECG to 0.5 seconds, and more.

     The most dangerous potential side effect nibentana occurrence or frequency zheludochkovyh departments, including polymorphic ventricular tahiaritmiyu type "pirouette." In such cases, intravenous drug potassium, magnesium, as well as more frequent stimulation of the heart or intravenous? - Adrenostimulyatorov, atropine.

     Since the introduction nibentana also possible violations of taste sensations ( "metal" taste in his mouth), a "hot" or "cold", DLR in the eyes, dizziness, MEDOSIL throat. In some cases probable aetiology.

     Nibentan not shown when expressed aetiology, QTc interval extension of more than 440 ms, while gipokaliemii and gipomagniemii. Because of the risk aritmogennyh effects of medication should not assign patients with predserdnymi, zheludochkovymi ekstrasistoliyami and unstable ventricular tahiaritmii epileptic.

     Thomas issuance : 1% injection of 2 ml ampoules (20 mg).

     Storage : List B.

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