NEOMITSINA SULFAT (Neomycini sulfas).

     A set of antibiotic neomycin (A neomycin, neomycin B, neomycin S) generated in the life of radiant fungus (aktinomitseta) Streptomyces fradiae or related microbes.

     Synonyms : Kolimitsin, Mitserin, Soframitsin, Framitsin, Actilin, Bykomycin, Enterfram, Framycetin, Myacine, Mycifradin, Neofracin, Neomin, Neomycinum, Nivemycin, Soframycine etc. 0-2, 6-Diamino-2, 6-didezoksi- a D glyukopiranozil- - (1-> 4) - O [0-2, 6-diamino- 2, 6-didezoksi- -L- idopiranozil- b (1 - 3), b -D- ribofuranozil (1-5)] 2-D-dezoksi- streptamin (neomycin B).

     Neomycin sulfate mixture neomitsinov sulphate.

     The white or yellowish white powder, almost odourless. The easily soluble in water, very little of alcohol. Gigroskopichen.

     Theoretical activity in the ED 680 1 mg, nearly producing activity is not less than 640 ED 1 mg; 1 ED activity with 1 µ g of chemically pure neomycin V (base).

     Neomycin has a wide spectrum antibacterial action. Effective for some gram (staphylococci, pnevmokokki, etc.) and gram (Escherichia coli, wand dysentery, proteus, etc.) microorganisms. For streptococcal maloaktiven. At pathogenic fungi, viruses and anaerobic flora is not operating. Stability of microorganisms to neomycin develops slowly and in small measure. The drug has bactericidal.

     In intramuscular a neomycin rapidly enters the blood; Therapeutic concentration remains in the blood for 8 -10 hours When administered drug absorbed poorly and almost has only local effect on the micro intestines.

     Despite the high turnout, neomycin is currently limited, due to its high nefro- and ototoksichnostyu. When parenteral use of the drug could experience kidney failure and nerve damage, audible up to a full hearing. It may develop neuro-muscular heat conductivity.

     When ingestion of toxic neomycin usually does not have, but if there is a violation renal excretory function, it is possible accumulation in the blood serum, which increases the risk of side effects. Moreover, in violation of the integrity of the mucous membrane intestines, and liver cirrhosis, uraemia intake of neomycin ulcers may increase. After intact skin does not cover drug absorbed.

     Assign neomycin sulfate interference in the gastrointestinal tract infections caused by susceptible to the microorganism, including enteritis caused by resistant to other antibiotikam- microorganisms, the operation of the digestive tract (for bowel disease).

     Locally applied when introducing skin diseases (piodermiya infected with eczema, etc.), wound infection, conjunctivitis, keratitis and other eye diseases, etc.

     Neomycin member of the vegetable <<Sinalar- N>> (see) <<Lokakorten- N>> (see).

     Inside nominated in the form of tablets or solutions. Doses for adults : single 0.1 - 0.2 g, 0.4 days in infant and pre-school children ages designate 4 mg / kg 2 times a day. The course of treatment is 5 to 7 days. While the appointment of neomycin sulfate inside a much larger doses : adults on 0.2 - 0.5 g per reception, daily doses of 1 to 2 g or more.

     For infants can be prepared antibiotic solution containing 1 ml of 4 mg drug, and to tell them to receptions so much how many millilitres of kilograms of body weight.

     To pre-designate of neomycin in 1-2 days.

     Out but use neomycin as solutions or ointments. Applied solutions for sterile distilled water containing 5 mg (5000 ED) drug in 1 ml. Under the dose of the solution should not exceed 30 ml, the daily 50-100 ml.

     Total 0.5% ointment applied once, must not exceed 25-50 g, 2% masi-5 - 10 g; During the day-50-100 and 10-1920

     Neomycin sulfate in the local application of well tolerated. When ingestion sometimes nausea, vomiting less, liquid stool, allergic reactions. The long reception neomycin could lead to the development of candidiasis.

     Neomycin is not suitable for kidney disease (principally, nephritis) and hearing nerve (see also Kanamitsin). Do not use neomycin with other antibiotics, and have ototoksicheskoe nefrotoksicheskoe Effects (streptomycin, digidrostreptomitsin, monomitsin, kanamycin, gentamicin).

     If there during treatment neomycin noise in the head, allergic events and the detection of protein in the urine need to accept the drug.

     Appointment pregnant requires some careful (see Kanamitsin).

     Method of production : tablets of 0,1 and 0,25 g, in vials of 0.5 g (50000 ED); 0.5% and 2% ointment (in the box on 15 and 30 g).

     Storage : List B. In dry place at room temperature. Neomycin sulfate solutions were prepared before consumption.

     Rp. : Tab. Neomycini sulfatis 0.1

     N.10

     D.S. At one pill two times a day

     Rp. : Neomycini sulfatis 0.5

     D.t.d. N.3

     S. Outside. For washing wounds.

     Wrap before consumption of 100 ml distilled water or isotonic sodium chloride solution

     R p. : Ung. Neomycini sulfatis 2% 15 0

     D.S. Outside. For lubricating skin (with piodermii)

     Neogelazol (Neogelasol). The aerosol product containing neomycin, geliomitsin, metiluratsil auxiliary substances and hladon-12 propellent.

     Available in glass bottles aerosol plastic cover on 30 and 60 grams in aluminum cylinders to 1946 Cylinders fitted Spray valves continuous operation. Clicking on the valve from the cylinder out foaming mass of yellow Darkling in air.

     In the container with a capacity of 30 g contains neomycin sulfate 0.52 g, 0.13 g and geliomitsina metiluratsila 0,195 g; In bottles 46 and 60 grams, respectively, 0.8 and 1, 04 g, 0.2 and 0.26 g , 0.3 and 0.39 g.

     Aerosol operates in gram and gram-negative microorganisms and accelerates healing of infected wounds.

     Applied in introducing diseases of skin and soft tissue : piodermii, carbuncles, boil (after the autopsy and surgical treatment), infected wounds, trophic ulcers, etc.

     Penistuyu mass to cause skin surface (1-5 cm distance), 1 to 3 times daily. The course of treatment was 7 - 10 days.

     Using the drug can be observed around the site causing hyperemia, itch.

     Product : in aerosol containers; Before using the cylinder several times to shake.

     Storage : in the dark place at room temperature, away from the lights and heaters.

     Sofradeks (Sofradex). The eye-ear drops, in 1 ml containing 5 mg neomycin (framitsetina), 0.05 mg gramicidin (see), and 0.5 mg dexamethasone (as metansulfobenzoata sodium).

     Accordingly, the content of the beginning, drops have bactericidal, and the anti-anti-inflammatory. When applied blefaritah, allergic and infectious conjunctivitis, iridotsiklitah and other inflammatory eye diseases, as well as vospalitelnoallergicheskih middle ear disease.

     Assign with eye diseases and 1 to 2 drops every 1 to 2 hours, then 1 - 2 - 3 drops four times a day. If ear infections buried in the ear of 2 to 3 drops of 3 - 4 times a day and a tampon, cotton products.

     Drops can appoint to viral and fungal diseases, eye, the eye of tuberculosis. It should be borne in mind the possibility of increasing the inner pressure (properties dexamethasone).

     Product : in vials of 5 mg.

     Storage : Keep in a cool place.

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