NEBIVOLOL (Nebivolol).

     (+-) A, A1- [Iminobis (methylene) bis [fluorine-6-3, 4-dihydro] -2 N-1- benzopiran-2- methanol].

     Synonym : Nebilet, Nebilet.

     Kardioselektivny V1- adrenoblokator long periods. Has sosudorasshiryayuschim actions, which may be linked to the stimulation of the synthesis of NO in endotelii receptacles. Not having a negative impact on lipid exchange.

     Rapidly absorbed, bioavailability of approximately 12% in patients with "fast" and nearly 100% in patients with "slow" metabolism, T1 / 2, 10 and 50 h, respectively; Being biotransformation in the liver out with urine and faeces.

     Applied with arterial hypertension and CHD (strokes voltage).

     Is the interior (not liquid during or after eating) to 0,005 grams (5 mg) once a day one (with kidney failure to 0.0025 g (2.5 mg) per day). Antihypertensive effect usually develops after 1-2 weeks and reaches a maximum at 4 weeks.

     There is evidence of drug use in chronic heart failure.

     Possible side effects : headache, dizziness, weakness, neuralgia, aetiology, atrioventrikulyarnaya blockade worsening peremezhayuscheysya leg, bronchospasm and others.

     The drug is contraindicated in aetiology, weakness syndrome sinusnogo node atrioventrikulyarnoy blockade II-III extent violations of peripheral blood bronhoobstruktivnyh diseases violations of the liver of pregnancy.

     Be wary designate diabetes (possible masking signs of hypoglycemia), hyperthyroidism (empted tachycardia), a propensity to allergies.

     Product : pills to 0,005 grams (5 mg) (No. 7, 14, 28).

     Storage : List B.

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