NADROPARIN CALCIUM (Nadroparin calcium).

     Synonym : Fraksiparin, Fraxiparin.

     Is limestone salt depolimerizovannogo heparin derived from pig intestines mucous membranes. The average molecular weight 4000-5000 Dalton.

     Provides direct antikoagulyantnoe action related to the direct inhibition of termination Ha and a II, as well as the increased blocking of antitrombina III factor Ha.

     It has antiinflammatory and immunosuppressive properties, several reduces cholesterol and? - Linoproteinov in blood serum.

     In a subcutaneous bioavailability of 98%, S-max 4-6 h, T? - 3.5 h (with the re-introduction of 8-10 h).

     Has a quick and relatively long (compared with the usual incidents) antitromboticheskoe up at relatively lower antikoagulyantnoy activity.

     Applied nadroparin calcium (and other low incidents) in orthopaedic surgical practice and to prevent thromboembolitic complications for treatment (resorption) deep venous thrombosis, and pulmonary artery embolism, acute coronary syndrome and other pathological conditions involving tromboobrazovaniem. Using well as prevention giperkoagulyatsii in extracorporeal circulation during hemodialysis.

     Enter usually subcutaneously (fibre in the abdomen) 1-2 times a day, sometimes intravenously (by indicators such as blood clotting).

     To prevent deep vein thrombosis and pulmonary embolism in the surgical intervention to impose on 0.3 ml subcutaneously (2850 IU) for 2-4 hours before the operation, then one every day in a 7 day; In orthopedic operations, according to the body mass index on 0,2-0,4 ml (38 IU / kg) 1 every day before and 3 days after the operation, then 0,3-0,6 ml (57 IU / kg) for a period of not less than 7 days .

     When treatment also increased deep vein thrombosis and pulmonary embolism are subcutaneously, depending on the weight of 0,4-0,9 ml (0.1 ml per 10 kg of body weight), 2 times a day during the 10 day transition to the indirect anticoagulants .

     In unstable angina and acute heart attack without super Q injected bolyusno rate of 86 IU / kg subcutaneously to the same dose of 2 times a day for 4-8 days.

     In applying the drug could haemorrhage and thrombocytopenia, allergic reactions (local and general), rare-bruised in a field.

     Nadroparin calcium is not suitable for thrombocytopenia, and the inclination to bleeding, including stomach ulcers, in violation of cerebral circulation, with the pregnancy. In the process of treatment should be determined number of platelets.

     Antagonist in drug overdose (increased bleeding) is Protamine sulfate (see).

     Fraksiparin not be used in conjunction with antiagregantami (including acetylsalicylic acid), as well as NPVS and anti.

     Product : injection of disposable syringes to 0.3; 0.6; 0,8 and 1 ml (9500 IU / ml and po0, 6; 0,8 and 1 ml (1900 IU / ml - Fraksiparin forte).

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