Bumetanide (nadolol)
NADOLOL (Nadolol) *. 2, 3 - cis-1, 2, 3, 4-Tetragidro-5- [2 - Oxy-3 (tert butilamino)] propoksi-2, 3-naftalindiol.
Synonyms : Corgard, Anabet, Betadol, Corgard, Nadic, Solgol. b-Adrenoblokator indiscriminate (b blocks 1 and 2 b-adrenoretseptory). Is long action. The half-20 - 24 h (the half-propranolol-2 - 4 h pindolola-3 - 4-hour, metoprolola-3 - 5 h, atenolol-6-9 p). Do not interfere inotropnogo action to attack.
The drug has antianginalnoy activity, and is used to treat coronary heart disease. Also effective in hypertensive disease (mostly in the early stages).
Assign inside (in the form of tablets), regardless of the meal. Due to the prolonged effects can be applied one time (sometimes 2 times) a day.
When ischemia take from one 40 mg once a day.
After 3-7 days can increase the dose to 80-160 mg / day (seldom to 240 mg). Dose regulated depending on the effect; In the event of excessive dose reduces aetiology. When hypertension appoint 40 80 1 mg once a day, gradually (with a one-week intervals) increased the dose to 240 mg / day (1 - 2 admission). Diuretics can be used simultaneously or vazodilatatory.
При применении надолола возможны в отдельных случаях явления утомления, бессонница, парестезии, сухость во рту, брадикардия, желудочно-кишечные расстройства.
The drug is contraindicated in bronchial asthma and a propensity to bronhiolospazmu, sinusovoy aetiology and blockade heart II or III level, kardiogennom shocked with pulmonary hypertension, "long" heart defect. It should appoint a drug for women during pregnancy and lactation. Caution is needed in the renal and liver failure, diabetes.
As for the treatment of other b-adrenoblokatorami, lifting the drug should be gradually (within 2 weeks) lower dose.
Product : pills to 20; 40; 80; 120, and 160 mg (0.02; 0.04; 0.08; 0.12 and 0.16 g) in sklyankah 100 and 1000.
Storage : List B. At room temperature, in the dark place.
Korzid (So rzid e) is a combination drug, a pill containing 40 or 80 mg and 5 mg nadolola diureticheskogo drug bendroflumetiazida close in structure and action to dihlotiazidu. Is applied for the treatment of hypertension.
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