MIELOSAN (Myelosanum).

     Bis metilsulfonovy broadcast butanediol-1, 4.

     Synonyms : Busulfan, Busulfan, Busulphan, Citosulfan, Leukosulfan, Mielucin, Misulban, Mitostan, Myeleukon, Mylecytan, Myleran, Mysulban, Sulfabutin and others.

     The white crystalline powder. Very little is soluble in water and alcohol,

     Has Setback mieloidnuyu impact on the fabric. Selectively oppresses granulotsitopoez and gives antileykemichesky effect in chronic mieloleykoze. The operation is mainly to reduce the number of immature granulotsitov.

     Applied with chronic mieloleykoze (leykemicheskaya form).

     Assign inside of 2 mg (0,002 grams) 1 to 3 times a day.

     In case of a crisis of chronic mieloleykoza, accompanying moderate splenomegaly, and increased leukocyte count to 200 ? 10 9 / L, 4-designate 6 mg / day (1 - 3 admission). In sharply enlarged spleen and leucocytosis (leukocyte count, more than 200 x 10 9 / L) daily dose increased by 8 to 10 mg (2 - 3 admission), and then reduced to 6 - 4 mg, when the number of cells is less than 200 x 10 9 / l. In reducing the number of cells to 50 x 10 9-40 x 10 9 / L, daily intake should not exceed 4 mg. The course of treatment ends with blood remission, which is usually at least 3 to 5 weeks after the start of treatment.

     Higher doses for adults inside : single 0,006 g (6 mg), daily 0.01 g (10 mg).

     When relapse mieloleykoza to repeat courses, determine dose depending on the number of cells in the peripheral blood and the course of the disease.

     By mielosanu is sustainability, and effectiveness of the treatment time is reduced. To achieve the desired effect in these cases, increasing the dose, but that is unsafe. Increase the dose should be handled with great care, and there must be a systematic study of blood during and after treatment.

     In overdose mielosana depressing effect on the blood could spill over into mature granulocytes and platelets development granulotsitopenii and thrombocytopenia with haemorrhage. Blood analysis should be done at least once every 5 days, with a decrease in the number of cells to 50 x 10 9 / L -40 x 10 9 / L every 2 days. During clinical remission study of blood and blood to produce at least two times a month.

     When expressed anaemia shows blood transfusions or eritrotsitnoy mass with oppression leykopoeza stimulants leykopoeza, enabling the number of blood transfusions, leykotsitnoy mass; Designate ascorbic acid, vitamin C, et al.

     When treating mielosanom can see vascular dystonia, a temporary amenorrhea, skin pigmentation, the oppression of sexual function in men.

     The drug is contraindicated in acute and subacute leukaemia, and worsening of chronic mieloleykoza if he has the type of acute leukemia in aleykemicheskih subleykemicheskih forms and chronic leukemia; When expressed thrombocytopenia.

     Product : pills to 0,002 grams (2 mg).

     Storage : List A. In the dark spot.

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