MIELOBROMOL (Myelobromolum). 1, 6-Dibrom-1, 6-didezoksi-D- Mannitol.

     Synonyms : Dibrommannit, Dibromomannitol, Mitobronitol, Mitobronitolum.

     The white crystalline powder. Little is soluble in water. In water solutions gradually hydrolyses.

     Like mielosanu has mieloidnuyu inhibitive effect on tissue and is used to treat chronic mieloleykoza. In the operation mielobromol different from mielosana, it is effective in resistance to mielosanu.

     Assign inside of 0.25 grams a day every day for 3 to 6 weeks before clinical signs of remission. With the rapid decline in the number of leukocyte reduced the dose to 0,125 grams per day. With the number of peripheral blood leukocyte count less than 20 x 10 9 / L switch to supportive therapy in the 0,125-dose of 0.25 g 2 times in the 7 - 10 days. Heading dose is usually 6 to 7 g.

     Can cause nausea, vomiting, diarrhea. The most serious complication thrombocytopenia. When the number of platelets less than 100 x 10 9 / L designate blood.

     Early treatment mielobromolom, blood tests produce three times a week.

     The drug is not suitable for hemorrhagic diathesis. Do not assign mielobromol conjunction with other drugs and therapy combined with radiation therapy.

     Product : pills to 0.25 grams in a package of 100 pieces.

     Storage : List A. In a dry, cool place.

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