Miarsenol (myarsenolum)
MIARSENOL (Myarsenolum). 3 3'- Diamino-4 4'- dioksiarsenobenzol- N, N'Methanesulfonate sodium bis.
Similar drugs are produced abroad under the title : Myoarsemin, Myosalvarsan, Sulfarsenol, Sulfarsphenaminum, Sulfostab, Thiosarmin.
Lightweight amorphous powder light amber. Very easily soluble in water; Almost nerastvorim in alcohol and ether. Contains 18, 2, 19, 2% arsenic.
Miarsenol is organic arsenic compounds; Chemical structure and the mechanism of close to novarsenolu. Has chemotherapeutic activity in spirohetozah and some diseases related to the simplest.
Mechanism of action due to the ability to block sulfgidrilnye (tiolovye) enzyme system microorganisms and thereby violate their body during normal metabolism.
Miarsenol applied for the treatment of syphilis.
Enter intramuscularly (in the upper outer quadrant of the buttocks) long (5 to 6 cm) needle. Diluted dissolve in 2 ml (regardless of dose), sterile water for injection room temperature. For people with high Greatness miarsenol can dissolve in the same amount of 1% solution of novocaine. Solutions must be absolutely transparent. For each patient solution prepared separately, immediately before use. Enter drug slowly. Injections for 2 hours before or 2 hours after meals.
Ad hoc, and daily doses depend on the course of the disease, age and general condition of patients.
The highest single dose drug for adults intramuscularly 0.6 g (1 every 5 to 6 days).
Miarsenol like novarsenolu arsenic and other drugs can cause different side effects : jaundice, hepatitis, and others polinevrit
Contraindications : individual neperenosimost, acute infectious diseases, acute gastrointestinal diseases, liver and kidney failure, diabetes, but did not diet, Ray, hemorrhagic diathesis, tuberculosis, the disease of central nervous system, visual system, chronic intoxication (alcohol, mercury, lead, etc. .) .
Do not appoint miarsenol pregnancy.
После острых инфекционных заболеваний (грипп, ангина) применение допускается после полного исчезновения всех симптомов перенесенной болезни и при общем хорошем самочувствии больного, но не ранее чем через 5 - 6 дней после нормализации температуры тела.
Product : powder in capsules of 0.15; 0.3; 0.45 and 0.6 g.
Storage : List A. potted sealed in a cool place protected from the light.
Before use miarsenola should carefully examine vials. If found cracks in the glass, sintering and change color drug use is not the last. The drug should be freely peresypatsya in vials, not prilipaya to its walls and forming lumps. It should be evenly coloured in normal color and to be dissolved. In a deviation from the norm and there is doubt as to use another drug vials.
Great solution to the air leads to a significant oxidation and makes it unfit for consumption.
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