MONTELUKAST (Montelukast).

     Sodium salt 1 -[[[( R) - m-[(E) -2 - (7-chloro hinolil) - vinyl ]-?-[ o - (1-methylethyl oksi-1-) fenetil] benzyl ] thio] - methyl] cyclopropane acetate.

     Synonym : Singulyar, Singular.

     New bronhorasshiryayuschy preparation for action to close zafirlukastu (akolatu). Like zafirlukastu is blokatorom receptors leykotrienov (LTS4, LTD4, LTE4) and has bronhorasshiryayuschee and anti-inflammatory effect in bronchial asthma and other bronhospasticheskih state.

     When ingestion rapidly and completely absorbed, bioavailability of approximately 70%, P max -2-3 h; Biotransformation are in the liver, kidneys displayed.

     The main reasons for montelukasta are prevention and long-term treatment of asthma. For cupping the asthma, including asthma status, drug use.

     Assign adults and adolescents (15 years and older) inside in the form of tablets of 0.01 g (10 mg), 1 time per day (evening). Children aged 6-15 are encouraged in the form of chewing tablets of 0,005 grams (5 mg) once a day, 1 (evening). Children under the age of 5 years product is not nominated (for lack of data).

     Montelukast is usually well. There headache, diarrhoeal phenomenon, swelling of the mucous membrane nose, cough, increased activity (induction) liver enzymes.

     Contraindicated in pregnancy, breast-feeding, in the age of 6 years.

     Treatment montelukastom, like other inhibitors leykotrienov and even new drugs should be under medical supervision. You must be ready Rapid edema bronhospazmov when they arise. Replacing montelukastom other LS (glucocorticosteroids, etc.) should be made gradually. Caution is needed in the appointment of patients with Disabilities liver.

     As with the potential induction of liver enzymes (tsitohroma R-450) should take into account the possibility of changing the pharmacokinetic (reduced activity) of LS-teofillina, anti kumarinovyh, terfenadina and others.

     Method of production : tablets of 0.01 g (10 mg); Chewing pill on 0,005 grams (5 mg) (No. 7, 14, 28).

     Storage : List B, with a temperature of 15 to 30 ° C in a dry, the dark spot.

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