MOEKSIPRIL (Moexipril).

     Ethyl ether (3S) -2-[(2S) N [(S) -1 - karboksi-3- fenilpropil] alanil] 1,2,3,4 - tetrahydro-6, 7-dimetoksi-3- izohinolinkarbonovoy acid .

     Synonym : Moeks, Moex.

     The white crystalline powder. Mg in the water.

     Alaninsoderzhaschy ACE inhibitor for long periods (up to 24 h). Structurally similar to ramiprilu and perindoprilu. Inside the deeterifikatsii to become active metabolite moeksiprilat.

     When ingestion absorbed poorly, bioavailability of about 13%, S-max 1,5 h, T? h-2-9; devoted primarily with feces in the form of metabolites.

     Applied with arterial hypertension.

     Assign inwards from 0.0075 g (7.5 mg), 1 per day (in conjunction with diuretikami nifedipinom or older, in violation of the functions of the liver and kidneys - 0.00375 grams (3.75 mg) per day); Supporting dose 0,015-0,03 g (15-30 mg), 1 per day.

     Possible side effects are basically the same as those scored.

     There are indications that the drug well tolerated in women with arterial hypertension in postmenopauze and may have antiosteoporoznoe effect, reducing the activity of osteoclasts.

     Contraindications : hereditary angionevrotichesky idiopathic edema, gipertroficheskaya cardiomyopathy, Aortic stenoses and renal artery stenoses, a violation of the liver and kidney, pregnancy, breast-feeding, childhood.

     It should not be used in conjunction with medication kaliysberegayuschimi diuretikami (giperkaliemii risk). While receiving lithium salts can lithium intoxication.

     Product : pills to 0,0075 and 0,015 grams (7.5 and 15 mg) (No. 7, 30).

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