MITOMITSIN (Mitomycin).

     Antitumor antibiotic isolated from Streptomyces caespitosus.

     Synonyms : Ametycine, Mutamycin.

     The structure has some similarities with bruneomitsinom. Contains uretanovuyu group and azaridinovoe ring.

     Permeating the cells mitomitsin become bi-and trifunktsionalnym alkiliruyuschim substances. It has a relatively weak immune activity.

     Adenokartsinome applied to the stomach (with ftoruratsilom and doxorubicin), carcinoma of the cervix, stomach, pancreas, bladder and other malignant tumors.

     Enter intravenously. Normal 2 mg dose of 1 m2 of body surface per day for 5 days. Courses repeated at intervals of 2 days.

     The drug can cause oppression and kostnomozgovogo peripheral blood, nausea, vomiting, diarrhea, stomatitis. It may strengthen kardiotoksicheskoe of doxorubicin.

     Contraindications : see Bruneomitsin, Doksorubitsina hydrochloride.

     Product : in vials of 5 or 20 mg (blue and purple crystals, water soluble).

     Storage : List A.

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