MIDODRIN (Midodrine) *. (#) Amino-N- -2 - (2, 5-dimethoxy - gidroksifenetil b) acetamide.

     Synonyms : Gutron (name drug firm Hafslund Nycomed Pharma AG) Alphamine, Gutron, Hipertan, Midamine and others.

     Available as hydrochloride.

     By chemically and pharmacologically similar to midodrin adrenalinopodobnym simpatomimeticheskim substances. Has sosudosuzhivayuschee and pressornoe (hypertension) effect. Like noradrenalinu and mezatonu stimulates primarily a-adrenoretseptory little impact on the b-adrenoretseptory; No significant impact on the frequency of heart, sokratimost attack, as well as bronchial muscles.

     Inside the midodrin hydrolyses education active metabolite de glimidodrina and aminouksusnoy acid (see Glycine).

     De glimidodrin is much more powerful sosudosuzhivayuschim (simpatomimeticheskim) action than the original compound midodrin; Thus midodrin as "prolekarstvo", which formed in the metabolism of an active substance (see Introduction, Adrenaline Dipivilat rest, Dipivefrin).

     Hydrolysis midodrina in the body occurs gradually, and sosudosuzhivayuschee action has been slower and more evenly than in the application noradrenalina, mezatona, fetanola.

     When ingestion midodrin well absorbed, it is found in plasma in 10 minutes; Maximum concentrated in 2 hours The half is 3 to 4 hours The drug and its metabolites derived mainly kidneys.

     Midodrin applied in the various types of hypotension : with Orthostatic Hypotension due to a violation of the sympathetic nervous system tone, with idiopathic Orthostatic Hypotension, secondary hypotension associated with infectious diseases, injuries, the use of medicines.

     Applied midodrin inside and intravenously.

     Inside designate usually one pill containing 2, 5 mg 2 (W less) per day, or 7 drops of 1% solution of 2 times a day. Once the clinical effects and long-term therapy to appoint 1 / 2 tablets (1 mg 25), 2 times a day, or 3 drops of 1% solution of 2 times a day. In some cases, first appointed to two tablets (5 mg) two times a day.

     Intravenous impose appropriate content of 1 mg (5 mg) two times a day.

     Treatment midodrinom must be controlled blood pressure and other hemodynamic variables. When the dose or individual sensitivity can hypertensive reaction, aetiology, increased sweating, pilomotornaya reaction ( "goose-flesh"), violations (delay increases) urination.

     The drug is not suitable for hypertension, feohromotsitome, spastic and obliteriruyuschih peripheral vascular disease, thyrotoxicosis, adenoma prostate gland, zakrytougolnoy glaucoma. Caution should be exercised when treating patients with congestive heart failure and arrhythmia, violations of kidney function.

     There should be appointed midodrin pregnancy.

     Method of production : tablets, containing 0.0025 g (2, 5 mg) midodrina, in a package of 20 or 50 pieces; 1% solution in vials to 10; 20 or 25 ml; 0.25% solution in 2 ml ampoules (5 mg in the ampoule) in a package of five vials.

     Storage : List B. In the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines