MIDANTAN (Midantanum). 1-Aminoadamantana hydrochloride, or 1-adamantanamina hydrochloride.

     Synonyms : Viregit, Adamantin, Amandin, Amantadini hydrochloridum, Amantadine hydrochoride, Amantan, Antadine, Atarin, Fluviatol, Gabirol, Mantadix, Mydantan, Paramentin, Protexin, Symmetrel, Viregit, Virofral, Virosol and others.

     The white crystalline powder bitter taste. Mg in the water, easy-to alcohol.

     The drug was originally proposed as an antiviral means effective against influenza viruses type A 2. Later it was found effective in parkinsonizme.

     The mechanism of therapeutic action in midantana parkinsonizme explain that it stimulates release of the allocation neyronalnyh depot and increases sensitivity of receptors to dofaminergicheskih mediator (start); Thus, even with decreasing start in bazalnyh nerve created conditions for the normalization of their neurophysiological processes. There is also evidence that the slowing midantan generate pulses in the central nervous system of motor neurons.

     Applied midantan with Parkinson's disease and parksinsonizme different etiology. The drug is effective mainly rigidnyh and akineticheskih forms less impact on giperkinetichesky syndrome (tremor).

     Information on the effectiveness midantana as proof neuroleptic syndrome contradictory. According to some authors, the drug may be used for this purpose, on the other, its application is impractical because in high doses, it is inefficient, and in large psychopathologically can exacerbate symptoms.

     Midantan is fast preparation, the effect usually comes in the first days of treatment.

     The drug may be nominated by themselves or in conjunction with other tools protivoparkinsonicheskimi : holinolitikami and L-Dov.

     Assign midantan inside after eating. Adopt from 0,05 - 0,1 g, the first two times, then 3 to 4 times daily. DSA dose of 0.2 - 0.4 g. duration of treatment 2 to 4 months.

     The drug is usually well. In some cases, there may be headache, insomnia, dizziness, weakness, diarrhoeal phenomenon. If necessary, reduce the dose.

     Milantan contraindicated in acute and chronic liver and kidney diseases, as well as 6 eremennosti. In connection with the possible excitation of central nervous system drugs should be appointed with caution to patients with mental illnesses, with thyrotoxicosis, epilepsy.

     Product : pills to 0.1 g-coated yellow, in a package of 100 pieces.

     Storage : List B. In dry place.

     R p. : Tab. Midantani 0.1 obd. N. 100

     D.S. At one pill 2 - 3 times a day

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