MEKSILETIN (Mexiletine hydrochloride) *. Methyl 1-(2, 6-ksililoksi) - ethylamine hydrochloride.

     Synonyms : Meksitil, Mexilen, Mexitec, Mexitil, Mexitilen, Moxitil, Tametil.

     On chemical structure similar to lidocaine and, like last it has antiaritmicheskoe effect. As lidocaine, complications related to drugs I team. Suppress fast transmembranny potassium ion current, has a stabilizing effect. Unlike lidocaine rapidly and completely absorbed by ingestion (Lidokain designate sometimes in the form of pellets inside, but the way it is of little use.) . Provided mainly through the kidneys.

     When applied zheludochkovyh ekstrasistoliyah, idiopathic or other zheludochkovyh adults, zheludochkovyh witness after myocardial infarction, to prevent fibrillation Poly with a severe heart attack; In adults, caused by an overdose of cardiac glycosides, and others.

     For acute edema violations rhythm impose meksiletin intravenously (in isotonic sodium chloride solution). First introduced at a rate of 0.17 mg / kg per minute for 15 minutes (with the help of a pump for infusions); Then, depending on the clinical re-mouth : in the first three hours of 0.03 mg / kg per minute (2 mg / kg per hour), then up to 12 hours or more, 0,008 mg / kg per minute (0.5 mg / kg per hour). For one hour before the end of infusion appointed interior 200 mg (1 capsule) drug. The transition to permanent oral appointed first 400 mg (2 capsules of 200 mg), followed by 200 mg (1 capsule) every 6 to 8 hours In some cases, a single dose is increased to 600 mg. Depending on the dose effect gradually.

     In long-term care meksiletin can be used as a medicinal form prolongiro bathroom (meksitil- depot) - capsules containing 360 mg drug. Daily dose of a drug that is usually 720 mg (2 capsules). If necessary, use more or fewer doses using conventional capsules meksiletina.

     Capsule (neprolongirovannye "and" prolonged ") proglatyvayut not liquid, squeezed water.

     In applying meksiletina to change the taste sensations, nausea, vomiting, eye, a violation of accommodation, ataxy, tremor, pareste spending, drowsiness, sputannost consciousness, dizziness.

     In some cases, medication may cause bradycardia, hypotension.

     It is aritmogennoe step : development zheludochkovyh ekstrasistoly, blinking predserdy.

     Contraindications : weakness sinusnogo hub, aetiology, hypotension, expressed heart failure, acute renal and liver understate statochnost.

     The drug crosses the placenta and enters the mother's milk, so it should not appoint women in pregnancy and breastfeeding (with the exception of the living testimony).

     Method of issuance : capsules in 50 mg and 200 in a package of 30 pieces; In kapsulah- depot to 360 mg in a package of 20 pieces : 2, 5% solution in ampoules and 10 ml (250 mg).

     Storage : List B.

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