METATSIN (Methacinum). 2-Dimetilaminoetilovogo acid ester benzilovoy yodmetilat.

     Synonym : Metacinum iodide.

     White or white, with a slightly yellowish sheen crystalline powder. It is soluble in water (1:200). Aqueous solutions (pH 4, 0, 5, 0) + 100 to sterilize 'C for 30 min.

     Metacin is very active m-cholinolytic funds. As a quarternary ammonium compounds, it does penetrates through the blood-brain barrier and is therefore selective peripheral holinolitikom force.

     At peripheral holinoretseptory metacin is stronger than atropine and spazmolitin. The effect on bronchial muscles more active than atropine. Most suppresses the secretion of salivary glands and bronchitis. Oesophagus relaxes smooth muscle, stomach, intestines. However, it has a much smaller midriaticheskoe effect than atropine, which apparently stems from the fact that it is difficult to penetrate through gematooftalmichesky barrier.

     Applied metacin as holinoliticheskogo and skin means disease, accompanied by cramps gladkomyshechnyh bodies.

     Metacin very effective for stomach ulcers and chronic gastritis. It eliminates motor dysfunction of stomach and duodenal ulcers, normalizes motor; Superior has an effect of atropine.

     Metacin can be used in treatment of patients ulcers in combination with other drugs.

     Metacin a highly effective tool for edema and renal colic liver.

     In practice anaesthetics used to reduce salivatsii bronchial glands and secretions, as well as to reduce bronhiolospazma and circulatory violations that may result from narcosis and irritation wandering nerve branches. Relatively with atropine metacin more convenient to use because, with less midriaticheskim effect, it provides an opportunity to be in operation for the change in diameter missed. For sedation metacin preferable because the increase was less than the heart, and he acts on the bronchodilatory exceeds atropine.

     Metacin can be used to remove the uterus increased excitability in danger of premature births and miscarriages later, for sedation operations Caesarean section. The use of the drug reduces the amplitude, duration and frequency of the uterus.

     Metacin is an effective tool for lowering tone and reducing motion activity oesophagus, stomach and duodenal ulcers in their X-ray study.

     Metacin applied inside and parenteral (under the skin to the muscles and veins). Inside designate metacin (to food) to 0,002 - 0,005 grams (2 to 5 mg) 2 - 3 times a day. The course of treatment is continuing normally 2 to 4 weeks. Under the skin, the muscles and veins are 0.5 to 2 ml of 0.1% solution.

     In practice anaesthetics metacin give these doses intravenously for 5 to 10 minutes, intramuscularly for 20 - 30 minutes until narcosis.

     The highest single dose for adults : inside 0,005 g; Under the skin, intramuscular injection in the veins and 0,002 g; The highest daily dose : 0,015 g inside, under the skin, intramuscular injection and non 0,006 g.

     Metacin usually well. Unlike similar tertiary amines (amizil, arpenal etc.), as well as atropine metacin not cause side effects associated with the impact on the central nervous system. Less also expressed tachycardia, midriaz, changing accommodation. In overdose possible side effects associated with peripheral cholinolytic action.

     The drug is contraindicated in glaucoma (especially when zakrytougolnoy form) and isolationist prostate gland.

     Method of issuance : pills to 0,002 g; 0.1% solution of 1 ml ampoules.

     Storage : A. In a list ukuporennyh banks of the dark glass; Tablets and capsules, in the dark place.

     Rp. : S for l. Me tha ini with 1 ml 0.1%

     D.t.d. N. 5 in a mpull.

     D.S. At 0.5 to 1 ml (under the skin, intramuscular injection or vein)

     Rp. : Ta b. Me thacini 0,002 N. 10

     D.S. On 1 - 2 2 tablets per day

Materials allowed to copy only with the active hyperlink to the handbook of medicines