METATSIKLINA HYDROCHLORIDE (Metacyclini hydrochloridum).

     Synonyms : Rondomitsin, Adramycin, Bialatan, Bivimicina, Brevicillina, Ciclobiotic, Duramicina, Dynamicin, Germiciclin, Globaciclina, Largomicina, Medomycin, Metaciclin, Metacycline, Methacycline, Minibiotic, Optimycin, Plurigram, Rindex, Rondomycine, Rotilen and others.

     The yellow crystalline powder, odourless, bitter-tasting. Slowly soluble in water (1:80).

     Semi tetracycline derivative. By setting different from oksitetratsiklina that contains a group of six metilenovuyu (CH2) instead of methyl and oksigruppy.

     For antimicrobial spectrum similar to other drugs in this group. Effective against most gram (staphylococci, pnevmokokki streptococci) and gram (esherihii, salmonella, shigella, aerobakter) microorganisms, as well as spirohet, rikketsy, leptospirs, agents psittacosis, fever, trachoma and some simple.

     Compared with tetracycline metatsiklin better absorbed by ingestion and the longer the blood, Cmax is 2-4 h, T? P -6-10; Easy to move into the organs and tissues in large concentrations found in the liver, kidney, blood and astsiticheskoy the liquid enters through the placenta; being biotransformation in the liver removed from the body slowly (mainly from urine and bile).

     Indications for use, possible side effects and contraindications are the same as those of tetracycline. Suffice effective in the treatment of gonorrhea.

     Assign inside (during or immediately after eating) for adults and children over 12 years of 0.3 g 2 times a day (with heavy able to 0.9 g / day). Children 8 to 12 years appoint 7,5-10 mg / kg 2-4 admission; Infection with heavy dose may be increased to 15 mg / kg per day. The course of treatment 7-10 days.

     Possible side effects are basically the same as in the application of tetracycline. Some patients experience metatsiklin better than others tetracycline. There are indications that metatsiklin is expressed photosensitization.

     The drug is not suitable for high sensitivity to tetracycline, nesaharnom diabetes, a violation of liver and kidneys, pregnant women and children up to 8 years. To designate caution when radiation.

     Product : Capsule for 0.15 and 0.3 g (N. 8, 16).

     Storage : List B.

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