MEZATON (Mesatonum). 1-(meta Oksifenil) -2 - metilaminoetanola hydrochloride.

     Synonyms : Adrianol, Almefrin, Derizene, Idrianol, Isophrin, Neophryn, Neo-Synephrine, Phenylephrini hydrochloridum, Phenylephrine hydrochloride, m-Sympatol, Visadron and others.

     White or white to slightly yellowish sheen crystalline powder and odourless. The easily soluble in water and alcohol. The solutions (pH 3, 0, 3, 5) to sterilize 100 'C for 30 min.

     Mezaton- adrenomimetichesky synthetic drug. It is a stimulant-adrenoreceptor; Have little impact on the b-receptor heart. It is narrowing arteriol and increased blood davlsniya (with the possible aetiology reflexive). Compared with noradrenalinom and via increases in blood pressure less dramatically, but over the long-term. Cardiac released by the mezatona growth (could even decrease).

     The drug raises pupil and could reduce inner pressure in glaucoma otkrytougolnyh forms.

     Unlike contests and noradrenalina mezaton is kateholaminom (it contains only one gidroksilnuyu group in aromatic nucleus) and little exposed to the enzyme katehol- O metiltransferazy (KOMT) involved in the biotransformation of catecholamine. Therefore mezaton more racks have a longer effect; Effective with the ingestion (but less than parenteral introduction).

     Mezaton applied to increase blood pressure in the collapse and hypotension associated with decreased vascular tone (but not with primary cardiac weakness), in preparation for the operation and during operations with intoxication, infectious diseases, hypotensive disease; To narrow vessels and reduce inflammation phenomena when vazomotornom and hay fever, conjunctivitis, etc.; adrenaline as a substitute in solutions anesthetics; to improve pupil.

     In sharp drop in blood pressure mezaton impose usually non dose of 0.1 - 0.3 - 0.5 ml of 1% solution in 40 ml of 5-20-40% glucose solution or isotonic sodium chloride solution; Enter slowly injections if necessary repeat. Enter drip 1 ml 1% solution in the 250-500 ml of 5% glucose solution.

     Under the skin or intramuscularly designate 0.3 to 1 ml 1% solution (adults), the inside-to 0.01 - 0.025 g 2-3 times a day.

     To narrow vessels mucous membranes and reduce inflammation phenomena used by lubricating or backfilling 0.25 - 0.5% solutions. For local anesthesia adds to 0.3 - 0.5 ml of 1% solution in 10 ml anaesthetic substance.

     To enhance maybe give konyunktivalny bag 2 to 3 drops of 1 - 2% solution mezatona. Midriatichesky effect less long than in the application of atropine (a few hours).

     Mezaton as other simpatomimetiki, raises maybe not affecting the accommodation.

     Higher doses for adults inside : single 0.03 g, 0.15 g daily; Under the skin and intramuscularly : single 0.01 g, 0.05 g daily; In vein : single 0,005 grams daily 0,025 g.

     Contraindications with hypertension, atherosclerosis, and the inclination to vascular spasm.

     Apply with care for chronic diseases attack, Ray and in the elderly.

     Method of issuance : powder; 1% solution in 1 ml ampoules.

     Storage : List B. Powder-well ukuporennyh banks orange glass; Capsules-in the dark spot.

     R p. : Sol. Me satoni 1% 1 ml

     D.t.d. N. in ampull 6.

     S. At 0.5 to 1 ml under the skin

     R p. : Sol. Me satoni 0.25% 10 ml

     D.S. For lubricating mucosal nose (or backfilling of 1 - 2 drops in the nose)

     R p. : Sol. M esatoni 1 ml 10%

     D.S. The eye drops (to improve pupil). On 1 - 2 drops in konyunktivalny bag

  Note. You can also use a cotton swab, smachivaemogo solution and laying down for a century.

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