Mesalazin (mesalazine)
MESALAZIN (Mesalazine). 5-Aminosalitsilovaya acid.
Synonyms : Asacol, Asalit, Claversal, Fisalamin, Mesacol, Tidocol, Salofalk, etc.
The structure is close to PARA- amino salicylic acid (PASK; See Sodium PARA- aminosalitsilat). Is the situation NH 2 group. TB activity has applied for the treatment of severe ulcerative colitis and Crohn disease. Is part salazosulfapiridina molecules (see) and its analogues, is also used for ulcerative colitis and Crohn disease.
Like other musk, mesalazin a fusion inhibitor prostaglandines and has antiinflammatory activity. Возможно, что это играет определенную роль в его специфическом действии. Mesalazin metabolised in the body to form N-acetyl-5-aminosalitsilovuyu acid.
Assign mesalazin inwards in the form of tablets to 0.4 g (400 mg), 3 to 6 times a day.
In applying the drug may nausea, diarrhea, pain in the stomach.
Mesalazin can be used in inefficiency and poor Portability salazosulfapiridina (sulfasalazina).
Mesalazin increases saharoponizhayuschee of sulfanilamidov, Effects kumarinov, methotrexate, spironolaktona, sulfinpirazona, furosemide, rifampicin. Усиливает ульцерогенное влияние глюкскортикоидов на слизистую оболочку желудка.
Contraindications to the extreme sensitivity of musk, and expressed violations of the liver and kidneys, with stomach ulcers and gastrointestinal cancers.
Pregnant appoint only emergencies. There should be appointed nursing mothers and children.
Product : pills to 0.4 g (400 mg), coated.
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