MERKAPTOPURIN (Mercaptopurinum). 6-Mercaptopurine (Monohydrate).

     Synonyms : Leykerin, Leukerin, Leupurin, Purinetol, Ismipur, Leukerin, Leupurin, Mercalenein, Mercaptopurine, Mercapurin, Mycaptine, Oncomercaptopurina, Purinethol.

     The yellow crystalline powder. Almost nerastvorim in water and alcohol, is soluble in hot water, and alkali solutions.

     Mercaptopurine is antimetabolitom purinov. In building 6-mercaptopurine close to adeninu (6-aminopurin) gipoksantinu (6-oksipurin) guaninu (2-amino-6- oksipurin).

     As a structural analogue - antimetabolitom these compounds are members of the nucleic acid (DNA, RNA), mercaptopurine violates the biosynthesis of nucleotides, suppresses the growth proliferating tissues and has a cytotoxic effect.

     Mercaptopurine applied in the treatment of acute leukemia (subacute), and worsening of chronic mieloleykoza, of the type of acute leukemia. In addition, when used horionepiteliome uterus (usually in combination with methotrexate) and the treatment retikulezov.

     The drug can be used in patients with acute leukaemia cases in developed resistance to antifolievym drugs-methotrexate,

     Assign inside for 2, 0-2, 5 mg / kg in one or two installments. If treatment is not effective, the daily dose increased to 5 mg / kg (maximum).

     Mercaptopurine as other cytotoxic drugs, has immunodepressivnoy activity, and in some cases (in doses of 50 to 150 mg / day) for the treatment of autoimmune zabolevanny : rheumatoid arthritis, chronic hepatitis, volchanochnogo jade and others (see Immunodepressivnye drugs).

     Mercaptopurine also applied for the treatment of psoriasis. Assign an adult to 0.05 g 2 - 3 times a day, 10-day cycles at intervals of 3 days. Total 3-to 4-cycle. Treatment is usually temporary effect.

     In applying mercaptopurine can have side effects : general weakness, defeat mucosal mouth, diarrhoeal phenomenon with vomiting and diarrhea. Like other cytostatics, mercaptopurine can cause leykoi thrombocytopenia.

     Treatment mercaptopurine should be under careful clinical and haematological control.

     In stark oppression gemopoeza expressed events, the preparation cancel appointed gemostimuliruyuschuyu therapy. During and after treatment (within 2 weeks) at least two times a week, to monitor performance of peripheral blood and blood kostnomozgovogo.

     A control function of liver and kidneys.

     Mercaptopurine is not suitable for radiation (leukocyte less than 3 x 10 / l blood), thrombocytopenia (platelets 100 x 109 / l), with liver disease, kidney and pregnancy.

     Product : pills to 0.05 g.

     Storage; List A. The well ukuporennoy packaging.

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