MEBGIDROLIN (Mebhydrolin)

     Chemical name : 2,3,4,5 - Tetragidro-2- metil-5- (fenilmetil) -1H- pirido [4,3-b] indole

     Description : Black or white with a white crystalline powder Cream. Almost nerastvorim in water and organic solvents.

     Pharmacology : The drugs act-antigistaminnoe, anti, protivozudnoe, antiekssudativnoe.

Lock gistaminovye H1- receptors lowers tone smooth muscles (bronchi digestive tract, womb), reduces the permeability of the capillaries and development of oedema, warns of itching. Weak blocks m holinoretseptory, it is expressed sedated and sleeping pills effects (permeates through the GEB in small quantities). The duration of effect can reach 48 hours.

     Application : Allergichesky rhinitis (seasonal, chronic), pollinoz, allergic conjunctivitis, urticaria, eczema, skin reactions to insect bites; Combination therapies zudyaschih dermatosis and asthma.

     Contraindications : Giperchuvstvitelnost, gastric ulcer disease and gastrointestinal cancers (in the phase of deterioration), inflammatory diseases of digestive tract, prostate gland hypertrophy.

     Restrictions : To Zakrytougolnaya glaucoma, pilorostenoz, epilepsy, a violation of a heart rhythm.

     Application of pregnancy and breastfeeding : Be wary designate pregnancy and breastfeeding.

     Side Effects : From the nervous system and sensory organs : increased fatigue, dizziness, parestezii; Using high doses of a slow-speed response, drowsiness, blurring the visual impact, the children paradoxical response : irritability, increased anxiety, sleeping, tremor.

For part of the digestive tract : rarely-dry mouth, nausea, heartburn, gastric mucous membrane irritation, pain in epigastralnoy area Diarrhoeal phenomenon, vomiting, constipation.

For the urinary system : violation of urination.

For part of the blood : rarely granulotsitopeniya, agranulotsitoz.

     Networking : Usilivaet effect of oppressive central nervous system.

     Dosing and Administration : inside (after eating). Adults and children over 10 years of 50-200 mg 1-2 times a day; Maximum dose : single 300 mg, 600 mg daily; For children from 5 to 10 years old, 100-200 mg / day, from 2 to 5 years 50-150 mg / day, up to two years in the 50-100 mg per day.

     Precautions : A caution against the use of liver and kidney disease (possible correction and dose intervals receptions). Be wary assign patients with potentially hazardous activities that require greater attention and psychomotor speed reactions.

Materials allowed to copy only with the active hyperlink to the handbook of medicines