MAPROTILIN (Maprotiline) *. (3 Metilaminopropil) dibenzo [b, e] - bicyclo [2, 2, 2] - octadiene.

     C inonimy : Lyudiomil, Ladiomil, Ludiomil, Ludionil.

     Maprotiline a compound structure chetyrehtsiklicheskoy close, but the texture, especially on the side chain of tricyclic antidepressants. At the same pharmacological properties similar to antidepressants in this group : weakens deprimiruyuschie effects rezerpina, aggravating fenamina. Is inhibitor monoaminov reverse takeover, but the difference is that on the critical constraint reverse takeover presinapticheskimi noradrenalina nerve endings. He makes a pressornoe noradrenalina and contests, a moderate holinoliticheskoy activity. MAO inhibition is.

     Maprotiline have antidepressant effects, accompanied by anksioliticheskim and mild sedative effect.

     When applied in various forms depressions, including rocket, neurotic, tsiklotimicheskie, involyutsionnye and others, accompanied by fear, irritability.

     Assign the inside, starting with doses of 50 mg three times a day; Then gradually increase the dose if necessary up to 300 mg per day. Older Persons appointed to 10 mg three times a day and, if necessary, increase the dose to 25-50 mg three times a day. Outpatient sick appoint 10 to 25 mg three times a day. In severe cases, Maprotiline happened in the veins in doses of 25-50 mg to 150 mg per day.

     Possible side effects, dry mouth, constipation, delayed urination; Violations accommodation expressed less than in the application of amitriptyline and imipramina. Sometimes there tachycardia and fluctuations in blood pressure. I can develop allergic reactions.

     The drug is contraindicated expressed in liver and kidney diseases and glaucoma, prostate gland adenoma.

     Method of issuance : Bean 10; 25 and 50 mg; 1, 25% solution in ampoules of 2 ml (25 mg).

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