Loratadin (loratadine)

	Loratadin (loratadine) �� (Loratadine). Ethyl ether 4 - (8-chloro-5, 6-dihydro-11 H-benzo [5,6] tsiklogepta [1,2-b] piridin-11- ilidene) -1 - piperidin- carboxylic acid. Synonyms : Klargotil, Klarisens, Klaritin, Klarifer, Klarotadin, Lomilan, Loratin, Loridin, Claritin, Clarotadinum, Klarisens, Lomilan, Loratin, Loridin. The white or whitish powder. Nerastvorim water well soluble in acetone, alcohol and chloroform. On chemical structure similar to loratadin tsiprogeptadinu ketotifenu and (see). Is blokatorom N1- gistaminovyh receptors for long periods. After a single admission into effect until 24 h, and therefore loratadin enough to take one every day. The distinguishing feature is the lack of preparation expressed sedative effect. Due to the length of, or lack of, at least, very little expressed sedative effect loratadin refer to protivogistaminnym drugs (N1- receptor blockers), the second generation. Absorbed quickly and completely, C max is 1,3-2,5 h, T? h-8, not crosses the blood-brain barrier; being in the liver biotransformation education deskarboetoksiloratadina active metabolite (T? about 28 h). Indications for use loratadina like other N1- receptor blockers (allergic conjunctivitis and rhinitis, urticaria, swelling Quincke zudyaschie Medicine, etc.). Adults and children over 12 years of age designated on the inside of 0.01 g (1 tablet or 2 tea spoons syrup); Children aged 2 to 12 years - 0,005 grams (? Tablet or one teaspoonful of syrup), 1 per day . The drug is usually well. In rare cases, can dry mouth, nausea, vomiting, increased appetite, sweating, arthralgia, mialgiya, giperkinezy. When pregnancy (and similar drugs) used only for health. Method of production : tablets of 0.01 g (10 mg) (No. 7, 10, 12); 0.1% syrup bottles in 100 ml and 120 (0,005 grams (5 mg) in 1 teaspoonful); 0.1% suspension for receiving inside of bottles of 30 and 100 ml. Storage : List B.
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