LEVONORGESTREL (Levonorgestrel).

     (17?) -13 - Etil-17- Oxy-18, 19-dipregn-4- en-20- in-3- it.

     Synonyms : Levonova, Mikrolyut, Mirena, Norplant, Postinor, Levonova, Microlut, Mirena, Norplant, Postinor.

     Is levovraschayuschim isomer gestagennogo drug norgestrel.

     The structure is close to noretisteronu.

     It stops gonadotropnuyu pituitary function, and reduces follikulostimuliruyuschego lyuteiniziruyuschego hormones, prevents implantation of a fertilized cells increases the viscosity of cervical mucus, thus impeding the progress of sperm.

     When ingestion rapidly and completely absorbed in the digestive tract, Cmax is 2 h; T? h-2-7; biotransformation exposed in the liver, presented with urine and faeces.

     Applied to contraception (alone and in combination with estrogen-see Combined estrogen- gestagennye drugs).

     Assign inside, subcutaneously (capsules) and vnutrimatochno.

     Inside use tablets to 0.75 mg 2 times with an interval of 12 hours (emergency contraception), or enter on one tablet (0.75 mg) or 1 pills (0.03 mg) daily, from 1 day of menstruation , for 21 days.

     The intrauterine system (Mirena) with levonorgestrel (to 0,052 grams) at 4-6 entering day menstrual cycle.

     Possible side effects : violation of menstruation, mastalgiya, nausea, headache, skin, the delay fluid girsutizm, depression, dermatitis, Alopecia.

     The drug is contraindicated in gormonozavisimyh tumors, and the inclination to hurt, otosclerosis, or acute liver tumors, urinary tract infection.

     Method of issuance : Capsule for subcutaneous implantation of 0,036 grams (N. 6); Tablets of 0.00075 grams (0.75 mg N) (4); Bean of 0.00003 grams (0.03 mg) (N . 35); intrauterine polymeric carriers for the 50 µ g (controlled release of levonorgestrel-20 µ g / day).

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