Levomepromazine (levomepromazinum)


LEVOMEPROMAZIN (Levomepromazinum). Metoksi- 2-10-(3-dimetilamino-2- metilpropil) - fenotiazina hydrochloride.
     Synonyms : Nozinan, Tizertsin, Dedoran, Laevomepromazin, Levomazine, Levomepromazini hydrochloridum, Levomepromazine hydrochloride, Levopromazin, Methotrimeprazine, Minozinan, Neozine, Neuractil, Neurocil, Nozinan, Sinogan, Tisercin, Veractil and others.
     By setting different from the situation in a aminazina 2 fenotiazinovogo kernel metoksilnoy Group (OSN3) instead of chlorine atom and additional methyl group alkilaminovoy (large) chain.
     On pharmacologically similar to aminazinu. The ability potentsirovat of narcotic substances and analgeziruyuschih and gipotermichesky effect from levomepromazina more pronounced; A strong adrenoliticheskoy activity on holinoliticheskomu and protivorvotnomu of losing aminazinu. Has expressed protivogistaminnoy activity. Has analgesic effect. It is relatively severe hypotension.
     For neyromediatornyh systems brain is much more powerful blocking action on noradrenergicheskie receptors than dofaminergicheskie.
     For treatment of Levomepromazine has been very active and speed of the sedative effect, which allows its use in acute psychosis. Unlike aminazina not increased depression, and it has some antidepressant activity. Timolepticheskogo terms of preparation, but it does not provide, and with typical endogenous depression is not a substitute for drugs or other modern antidepressants.
     Testimony to use levomepromazina are psychomotor initiate various etiology, involyutsionnye psychosis, maniacal stage manic depressive psychosis, anxiety paranoid schizophrenia, depression and other reactive psychotic state, with the underlying phenomena of anxiety, fear, anxiety and movement. In connection with intensive Acts of it is particularly effective in alarming condition, Manic oneyroidno- katatonicheskom institute. High efficiency levomepromazina also noted with alcoholic psychosis.
     Assign Levomepromazine inside and parenteral (intramuscularly, less intravenously). Treatment of patients are brought to injecting 0,025 - 0,075 g of the drug (1 - 3 2 ml, 5% solution); If necessary to increase the daily dose of 0.2 - 0.25 g (sometimes up to 0,35-0 , 5 g), intramuscular introduction to the 0,075-0.1 g in giving vein. As a man reassure patients receiving the drug gradually replacing the interior. Inside appoint 0,05 - 0,1 g (up to 0.3 - 0.4 grams) per day. Heading treatment start with a daily dose of 0,025 - 0,05 g (1 - 2 2 ml, 5% solution of 1 or 2 tablets of 0,025 g), increasing daily dose of 0,025 - 0,05 g to the daily doses of 0.2 - 0.3 g inside or 0,075 - 0.2 g parenteral (in rare cases to a daily dose of 0.6 - 0.8 g inside). By the end of treatment dose gradually and to appoint maintenance therapy 0,025-0.1 grams per day.
     For intramuscular of 2, 5% solution levomepromazina grow in the 3 to 5 ml isotonic sodium chloride solution, or 0.5% solution of novocaine and impose deep in the upper outer quadrant of the buttocks. Intravenous introduction to slowly; Solution preparation plants in the 10-20 ml of 40% glucose solution.
     For edema acute alcoholic psychosis designate intravenously 0.05 - 0,075 grams (2 to 3 ml of 2, 5% solution) preparation in the 10-20 ml of 40% glucose solution. If necessary to introduce 0.1 - 0.15 g intramuscularly for 5 to 7 days.
     In outpatient facilities Levomepromazine designate patients with neurotic disorders, elevated anxiety, insomnia. Diluted take inside in a daily dose of 0.0125, 0.05 grams (1 / 2 - 2 pills).
     In practice neurological drug is used in a daily dose of 0.05 - 0.2 grams of diseases involving pain syndrome (neuralgia troynichnogo nerve, movement of facial nerve, leaving zoster, etc.).
     Positive effect Application levomepromazina with zudyaschih Medicine.
     The drug is usually well. Possible side effects are the same as when applying aminazina but less in reality. In the picture extrapiramidale violations prevails akinetiko- hypotensive syndrome. Intramuscular injections painful.
     The drug is contraindicated in resistant hypotension, especially among older patients with cardiovascular decompensation, liver damage and haematopoietic system.
     Method of issuance : pills (pills) to 0,025 grams in a package of 50 pieces; 2, 5% solution of 1 ml ampoules in a package of 5 and 10 ampoules.
     Storage : List B. In the dark spot.

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