KOLHIKUM- DISPERT

     Synonym : Colchic speciosi alkaloid, Bezvremennika great asexual

     The drugs Effects : Reduces leukocyte migration in the hotbed of inflammation, suppressed phagocytosis mikrokristallov uric acid salts, thus protivopodagricheskoe effects (pain acute gout attack). It has also antimitoticheskim action, suppressing (fully or partially) in the cell division stage anafazy and metafazy prevents degranulyatsiyu neutrophiles. Lowering education amiloidnyh fibril, the development amiloidoza. During the first 12 h of treatment has improved more than 75% of patients. A 80% can cause adverse reactions from the digestive tract before clinical improvement or simultaneously with it. In a daily dose of 1-2 mg daily, with admission from 3 / 4 patients with gout reduces the likelihood of re-development of gout attacks. Warn attacks in patients with severe recurrent disease (family Mediterranean fever), lowers the activity of beta dofamin- gidroksilazy.

     Indication : Gout (acute attack), periodic disease (family Mediterranean fever).

     Contraindications : Giperchuvstvitelnost, liver and / or kidney failure, expressed oppression kostnomozgovogo blood, pregnancy, the period laktatsii.C caution. The elderly, cachexia, severe digestive tract infections and SSS.

     Side effects : Diarrhea, nausea, vomiting, stomach pains, seldom-radiation. With long-term use - myo, neuropathy, seldom-agranulotsitoz, gipoplasticheskaya anemia, Alopecia. Overdosing. Acute poisoning occurs among adults after receiving 20 mg and the children after receiving 5 mg. Chronic intoxication occurs among patients with gout, after receiving a total dose of 10 mg or more in a few days. Symptoms : through 2-6 h after administration into toxic dose-burning and MEDOSIL sore throat and mouth, to the male vomiting and difficulty swallowing, nausea, vomiting and thirst, and urination in male urinating, tenezmy and cramps (usually from depleted patients); gipokaliemiya, giponatriemiya and metabolic disorders (loss of fluids and electrolytes because slizisto- watery and / or hemorrhagic diarrhea). Often, the pain and tightness in the heart, in the future, paleness, hypothermia, cyanosis and dispnoe. Perhaps tachycardia development and the reduction of AD (up to the collapse). From the nervous system : gipesteziya, convulsions, paralysis. Possible death in the first three days due to cardiovascular and respiratory paralysis. After 1-2 weeks after cure intoxication may occur complete, sometimes lasting Alopecia. In some cases, the violations as kidneys, lungs and liver; Seldom-blindness. Treatment : symptomatic aimed at stabilizing the SSS. In / plazmozameniteli put in drip or 0.9% NaCl solution with dextrose and electrolytes (primarily K +), ECG monitoring; Digoxin (for sokratimosti attack). If necessary, antibiotikoterapiya. With increased pressure AGC-dexamethasone; If necessary carried puncture. When cramps in the stomach designate atropine, papaverin. It should not be used opiates. If necessary, or Oxygenotherapy IVL.

     Dosing and Administration : inside. Pills proglatyvayut is not liquid, liquid squeezed enough. In acute gout attack-first 1 mg (2 tablets), followed by 0.5-1.5 mg every 1-2 hours to relieve the pain. The maximum daily dose of 8 mg. Reappointment scheme treatment of acute gout attack not less than 3 days. In order to prevent acute attacks of gout, 0.5-1.5 mg daily or every other day during the (usually) three months.

     Special instructions : The treatment should be carefully haematological and clinical supervision. When expressed side effects from the digestive tract to reduce the dose or stop medication. By reducing the number of cells below three thousand / cells and platelets less than 100 thousand / mm reception cease to normalize blood picture.

     Networking : With the simultaneous application of cyclosporine (especially in patients renal nedochtatochnostyu) more likely myo development. To enhance deprimiruyuschih and simpatomimeticheskih LS. Tsianokobalamina violate intake. Errors and others LS causing mielodepressiyu, increase the risk of hemorrhagic and thrombocytopenia. Protivopodagricheskuyu activity reduces cytostatics (increase the concentration of uric acid) and zakislyayuschie urine LS; Oschelachivayuschie heighten the effect. The drug can be used in combination with allopurinolom and LS urikozuricheskogo action.

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