KETOTIFEN (Ketotifenum) *. 4, 9 Digidro-4- - (1-methyl-10 piperidiniliden H-benzo [4, 5] tsiklogepta [1 2-b] - tiofen-10- he [gidrofumarat).

     Synonyms : Astafen, Zaditen, Asmasedil, Asmen, Astafen, Histaten, Ketotisin, Poziten, Respimex, Totifen, Zaditen, Zasten.

     The drug has protivogistaminnoy and antiallergic activity. Activity related to the ability to inhibit the release of histamine and other mediators substances ( "slow-reacting substance arginine, limfokinov, etc.) from the fat cells to suppress the activation of platelets caused by the accumulation factor in respiratory passages Eosinophils have a locking effect on the N ~-receptors.

     The drug is well absorbed, the peak concentration in plasma was at 2 - 4 h after administration of the interior, the half to 21 h.

     Applied for the treatment (mainly to prevent attacks), bronchial asthma, allergic bronchitis, hay fever, allergies rinitov, allergic skin reactions.

     Assign inside adult for 0,001 g (1 mg) in the form of capsules or tablets two times a day (morning and evening with a meal). If necessary, take on 2 mg, 2 times a day.

     Children, depending on age and body mass designate smaller doses (1 / 3 - 1 / 2 - 2 1 pill twice a day).

     The drug can have a sedative effect and should be appointed with caution drivers transport operators, etc. Please note that the drug increases of hypnotics, sedatives and alcohol. Perhaps fewer platelets.

     The drug is contraindicated in pregnancy. Do not appoint him with oral antidiabetics and other drugs, which can cause thrombocytopenia. Those sensitive to the sedative action, appointing product in the first week of treatment at a reduced dose-0.0005 g (0.5 mg) per day.

     Method of issuance : capsules and tablets under 0,001 grams (1 mg); Syrup containing 1 ml of 0.2 mg medicine (100 ml of 20 mg).

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines