KETOKONAZOL (Ketoconazole). 1-CIS Atsetil-4- para-n- [2 - (2, 4-dihlofenil) -2 - (imidazol-1- mud ethyl) - 1, 3-dioksolan-4- mud) - metoksifenil- piperazine.

     Synonyms : Nizoral, Oronazol, Candoral, Cetonax, Fungocin, Fungoral, Ketonil, Ketozol, Micosept, Orifungal, Oronazol, Panfungol.

     Anti-drug groups from imidazolnyh derivative (see Clotrimazole). Important features are ketokonazola its effectiveness when administered, as well as its impact on surface and at systemic mycosis.

     The operation involved a breach biosynthesis ergosterina, triglycerides, and phospholipids to education cell membranes mushrooms.

     When drug ingestion well absorbed.

     Assign Ketoconazole in the surface and systemic mycosis : dermatomycosis and onihomikozah caused blastomitsetami; Mycobacterium nails of the head; Vaginalis Mycobacterium; Blastomitsetoze mouth and gastrointestinal tract and urinary organs and other internal organs mycosis.

     Oseltamivir can be used to prevent fungal infections in immunocompromised low resistance.

     Is inside one every day during meals. Doses for adults : in dermatomycosis-to 0.2 g (1 tablet) 1 every day in a 2 - 8 weeks; When onihomikozah and chronic candidiasis in the same dose to the full (with mycotic control) recovery (4-6 Weeks ); with the defeat of the oral cavity, gastrointestinal tract and urinary-1 - 2 pills a day for 2 weeks, followed by one pill a day to complete recovery (4 to 6 weeks). In systemic mycosis appointed in the first 2 weeks to 2 pills a day and then on one pill a day for several months.

     Oseltamivir appoint one pill a day; Deadline of a largely depends on the disease.

     For children over 2 years of daily doses of 0.05 g body weight to 20 kg and 0.1 g (1 / 2 tablets) in body weight 20 to 40 kg. Children under 2 years are designated only with the absolute testimony to the use of anti-drug.

     There is evidence of the use in the treatment of mycosis ketokonazola eye. Assign to one tablet (0.2 g) a day. With heavy losses cornea also used emulsion ketokonazola, prepared by ex tempore (1 pill to throw in 5 ml of 4, 5% solution of boric acid). Konyunktivalny bag buried in 5 to 6 times a day. This should take into account the possibility of irritants.

     Before ketokonazola possible nausea, vomiting, diarrhea, headache, skin itch and, less frequently, dizziness, drowsiness, arthralgia, Bitch, reduced libido, Alopecia; Liver function may be disrupted.

     Contraindications : pregnancy, breastfeeding, a violation of the liver and kidney, individual neperenosimost drug.

     We have to take a Antacids preparations holinolitiki, tsimetidin and its analogues (declining intake).

     When treating ketokonazolom picture should monitor blood type liver. Caution should be observed in the breach as pituitary and adrenal cortex.

     Product : pills (to risk) of 0.2 g (200 mg) in a package of 20 - 30-60 pieces.

     Storage : in the dark spot.

     There are performance ketokonazola in some form gormonozavisimyh prostate cancer. The effect due to inhibition androgenov education. Dose ketononazola 0.2 - 0.4 g every 8 hours The drug is androstendiola reduction in plasma.

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