IZOSORBID MONONITRAT (Isosorbide mononitrate). 1, 4, 3, 6-Diangidro-D- sorbita-5- mononitrate.

     C inonimy : Monizid, Monisid, Bonivix, Corangin, Duramonitat, Elantan, Isomonat, Medocor, Monit, Mononit, Monoclair, Monoket, Monizol, Mono-Mack, Olicard and others.

     Isosorbide mononitrate is a major metabolite of isosorbide dinitrate (Nitrosorbid). Based on current data, to vazodilatatornogo action it should continue to metabolizirovatsya Education Group N O.

     The nature of isosorbide mononitrate close to nitrosorbidu. However, compared with nitrosorbidom it has higher bioavailability and has a longer half-time (6 hours) after oral and intravenous.

     Antianginalny effect is through 30-45 minutes after administered orally and lasts until 8-10 hrs, as intravenously immediately after the start of infusion.

     Indications for use inside the same as for Nitrosorbid. In severe strokes, anginoznom status, pulmonary hypertension in terms of circulation, is injected. In severe deficiency levozheludochkovoy faster and has a direct effect of nitroglycerin.

     Inside with IBS in the treatment of heart failure appoint 0.02 g (20 mg) 2 - 3 times a day; In heavy conditions on the 0.04 g (40 mg) 2 - 3 times a day.

     In veins entering from 1 to 5 vials per day; Enter drip slowly at the rate of 5 to 15 µ g / kg per minute.

     Possible side effects and contraindications are the same as for other organic nitrates.

     Method of production : tablets of 0.02 g (20 mg) in a package of 50 pieces of pills to 0.04 g (40 mg) in a package of 20 pieces; 1% solution in ampoules and 1 ml (10 mg) in the package of 50 vials.

     Storage : List B. At room temperature, in the dark, dry place.

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