ÉÎÃÅÊÑÎË (Iohexol).

N, N'Bis (2, 3-digidroksipropil) -5-[N - (2, 3-digidroksipropil) atsetamido] 2, 4, 6-triyodizoftalamid.

     Synonym : Omnipak, Omnipaque.

     Iodine content of 46.4%.

     Available in the form of sterile solutions containing 1 ml 388, 518, 647 or 755 mg yogeksola (respectively 180,240,300, or 350 mg iodine. 1 ml).

     Iopanoic well soluble in water; Commodity solutions yogeksola (omnipak) contain additives as trisamin (see) and the sodium salt of limestone ethylene acid (N-to-Samara Edetat); The solution pH 6, 8, -7, 6.

     Referring to the so-called, non-ionic rentgenokontrastnym means. Unlike <metal> preparations were sodium salt and create in giving blood current high osmotic pressure, which can lead to undesired side events, omnipak osmomolyarnostyu is low (about 2, 5 times lower than that triombrasta).

     The viscosity of solutions of concentrations omnipaka 140,180, and 240 mg of iodine in 1 ml lower blood viscosity, and the concentrations of 300 and 350 ml of iodine in 1 ml - more than blood viscosity. Preparation is relatively little blood associated proteins. Quickly and almost presented unmodified form with urine (within 24 hours).

     Compared with other means triyodsoderzhaschimi rentgenokontrastnymi omnipak malotoksichen.

     Depending on the evidence, omnipak give blood vessels in the cavity, the subarachnoid space, as well as inside.

     Vnutrisosudistoe apply to the introduction of intravenous ekskretornoy urografii, angiography, flebografii.

     Concentrations of solutions and dose dependent on the evidence and the age of the patient.

     For production ekskretornoy urografii impose usually adults 40 80 ml preparation containing 300 or 350 mg iodine in 1 ml; Children weighing up to 7 kg per 1 kg of body weight 3 ml preparation containing 1 ml in 300 mg iodine; When body mass index more than 7 kg of 2 ml / kg of the same solution (not exceeding 40 ml).

     To enter via angiography arc 30-40 ml omnipaka containing 300 mg of iodine in 1 ml; For aortografii-40-60 mL of solution containing 350 mg of iodine in 1 ml; For peripheral arteriography (lower limbs) - 30-50 ml of the contents of 350 or 300 mg iodine in 1 ml. To enter kardioangiografii adults in the left ventricle and root via 30-60 mL of solution containing 350 mg of iodine in 1 ml; For selective coronary arteriography-4-6 ml of the same solution.

     For flebografii (lower limbs) to introduce 20-100 mL of solution containing 240 mg or Z00 iodine in 1 ml.

     In cavity (for artrografii, retrogradnoy endoscopic pankreatografii, holeangiopankreatografii, gerniografii, Hysterosalpingography) impose omnipak containing iodine 240,300, or 350 mg in 1 ml dose of 5 to 50 ml.

     X-rays inside to the gastrointestinal tract using omnipak containing 180 mg of iodine in 1 ml, in doses of 10 to 200 ml or omnipak containing 350 mg of iodine in 1 ml, in doses of 10 to 20 ml.

     Subarahnoidalno omnipak introduce adults and children to lyumbalnoy, breast and cervical mielografii and tomography bazalnyh tanks. Adults impose solutions containing 180,240 or Z00 mg iodine in 1 ml; Children only solutions containing 180 mg of iodine in 1 ml. Depending on the evidence, dose for adults is between 4 and 15 ml, for children from 2 to 12 ml. The total number of iodine in arachnoidal introduction should not exceed 3 g.

     Usually omnipak moved better than <ion> Radiocontrast drugs, but the side effects are also possible. Entering omnipaka in blood vessels could experience a sense of warmth, pain in the heart; Possible headache, nausea, vomiting, skin reaction (itching, burning). In mielografii may be headache, nausea, vomiting, pain in the back, neck, limbs.

     Application omnipaka contraindicated in pregnancy. Caution is necessary when using omnipaka to survey patients with serious liver and kidney functions, and thyrotoxicosis, and the tendency to allergic reactions.

     It confused omnipak Solutions with other medicines.

     Product : in bottles of 10 or 15 ml containing 180 mg of iodine in 1 ml; 10; 20 or 50 ml containing 240 mg of iodine in 1 ml; 10; 20; 50 or 100 ml containing iodine 300 mg of 1 ml; 20; 50 or 100 ml containing iodine 350 mg in 1 ml.

     Storage : in the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines