INSULIN- IZOFAN [CHELOVECHESKY GENNO- INZHENERNY] (Insulin-isophan [biosynthetic human])

     Description : Highly (chromatographic), monokomponentny swine isophane insulin protamine average duration of action.

     Pharmacology : The drugs-hypoglycemic effect.

Regulates exchange and deposit of carbohydrates, proteins and lipids in organah- target (liver, skeletal muscle, adipose tissue). Interacts with the specific receptor tsitoplazmaticheskoy cell membrane to form insulinretseptorny complex. By activation synthesis tsAMF (fat cells and liver) or directly penetrate the cell (muscle), insulinretseptorny complex stimulates intracellular processes, including induces synthesis of a number of key enzymes (glucokinase, piruvatkinaza, glikogensintetaza etc.). Hypoglycemic effect is the result of increased intracellular transport of glucose uptake and assimilation of its tissues, stimulating lipogeneza, glikogenogeneza, protein synthesis, reducing the speed of glucose biscuits (by reducing the breakdown of glycogen), etc. When a patient diabetes corrects metabolic changes that normalizes porous membranes for glucose, restores the balance between glikolizom and glikoneogenezom. In S / to a hypoglycemic effect begins after 1-3 h, reaches through the 3-18 hour lasts about 24 hours (parameters depend primarily on pharmaceutical form of insulin isophane and dose).

     Application : Diabetes mellitus type 1 (insulinzavisimy) and type 2 (insulinnezavisimy), including with partial resistance to the oral antidiabetics means pregnancy upcoming operational intervention, interkurrentnyh diseases.

     Contraindications : Giperchuvstvitelnost, hypoglycemia, insuloma.

     Side Effects : Gipoglikemiya (in high doses, or pass late meal, heavy physical activity, in the face of infections or diseases, especially diarrhea and vomiting accompanied by) : increased sweating, rapid heartbeat, tremor, sleep disorders, and prekomatoznoe coma, and others; hyperglycemia and diabetic acidosis (at low doses, passes injections, non-diet, in the face of fever and infections) : drowsiness, thirst, loss of appetite, Blush person prekomatoznoe and coma state; allergic reactions, skin rashes, angionevrotichesky edema, swelling of the larynx, anaphylactic shock; at the injection-hyperemia, itching of the skin, swelling, lipodistrofiya-in long-term use.

     Networking : Gipoglikemichesky effect reinforce MAO inhibitors, beta adrenoblokatory, sulfanilamidy, lower-glucocorticoids, oral contraceptives, drugs thyroid hormones, tiazidnye Diuretics, antidepressant drugs.

     Overdosing : Symptoms : signs of hypoglycemia, weakness, cold sweat, paleness of skin, heart, shaking, anxiety, nausea, a feeling of hunger, parestezii wrists arms, legs, lips, language, headache, sleeping; In severe cases, hypoglycemic coma.

Treatment : with weak hypoglycemia-immediate admission of glucose (glucose tablets, fruit juice, honey, sugar or sweet food); In severe hypoglycemia-a solution in glyukagona / m and then (if necessary) the appointment of 40% glucose solution w /.

     Dosing and Administration : Only S / of; To use a bottle gently vstryahivayut (for the full mixing with the solvent) until evenly turbid or milk colour content, immediately gaining the appropriate dose and type. Dose set individually. In monotherapies diabetes-1-2 times a day. The transition from injecting highly pig or human insulin does not require dose adjustment; Replacing or mixed bovine insulin dose reduced by 10%, except in cases where the daily intake does not exceed 0.6 ED / kg of body weight. Patients receiving a day and more than 100 ED, replacing insulin to be hospitalized.

     Precautions : A dose adjustment when changing diet, increased physical activity, surgery, infectious diseases, fever, disrupting thyroid function, adrenal, including disease Edison, glands (including gipopituitrizm), renal failure, liver disease progression during pregnancy and breastfeeding, those over 65 years of age. To use caution when intense mental and physical activity, including driving or managing different mechanisms, because in a significant mental or physical stress can decrease the ability to concentrate, mental and motor speed control.

Materials allowed to copy only with the active hyperlink to the handbook of medicines