INKAZAN (Incazanum). 3-Metil-8- metoksi-3H-1, 2, 5, 6 tetragidropirazino- [1, 2, 3, a, b] b-karbolina hydrochloride.

     Synonyms : Metralindol, Metralindolum, Metralindol.

     White or white with a slightly kremovatym white crystalline powder. Mg in the water, it is difficult to dissolve in ethanol.

     By chemically and pharmacologically similar to pirazidolom. Like pirazidolu is reversible MAO inhibitor type A, and activates noradrenergicheskie serotoninergicheskie processes in the CNS. Partly ingibiruet MAO type B. Has antagonism to action rezerpina, magnifies the effect fenamina, L-Dov, 5-oksitriptofana. Unlike pirazidola reinforces central feniletilamina effects. It stops the reverse takeover neyronalny monoaminov. Holinoliticheskogo do not have.

     Psychotropic activity inkazana includes timoanalepticheskoe effect in combination with catalytic component.

     Applied inkazan with depression different genesis (schizophrenia, manic-depressive psychosis, tsiklotimiya, cerebrovascular disease, etc.) dominated hypo and anergicheskih disorders. Most shows in vyaloapaticheskih, adinamicheskih depression with inhibition, as well as shallow depression with nevrozopodobnoy and malovyrazhennoy ipohondricheskoy simptompikoy.

     Patients with alcoholism drug designate Pichinde and adinamicheskih subdepressivnyh state during remission (outside severe cramping syndrome).

     Applied inkazan inside and parenterally intravenous (drip and struyno), or intramuscularly.

     Inside are in the form of tablets, from 25-50 mg, 2 times a day (morning and afternoon) and gradually increasing the dose in the next few days to 250-300 mg per day. Last admission preparation for the removal sleep disorders should be no later than 17 hours

     In protracted and therapy-resistant depression, as well as obstruction of swallowing tablets or contraindications to receive inside (gastrointestinal illness) inkazan can enter intravenous drip (40-60 drops per minute) or struyno of 1, 25% for the solution inkazana injection. For a daily dose of drip inkazana dissolve in the 250-500 ml isotonic sodium chloride solution, or 5% glucose solution. Treatment starts with the 50-mg dose and then gradually increase to 200-250 mg. Depending on the condition of the patient, the effectiveness and acceptability of intravenous drug inkazana still five to 15 day.

     With inkjet intravenously inkazana his daily dose of 50 to 150 mg (introduced slowly for 1 to 2 minutes). The course of treatment usually lasts five to 15 days.

     Intramuscularly inkazan be 1 to 2 times a day (in the morning) in doses of 25 to 150-200 mg within 1 to 3 weeks, and then designate the interior. To improve the efficiency of treatment to the simultaneous introduction of intramuscular and reception inside.

     If necessary, use a combination of tranquilizers and inkazana Neuroleptics (with schizophrenia) or with other antidepressants and tranquilizers (in the deep, protracted resistant endogenous depression, as well as involyutsionnoy Melancholy).

     Inkazan usually well. Lack of holinoliticheskogo allows for the preparation of patients (with glaucoma, the isolationist prostate gland, etc.), which can not receive antidepressants with holinoliticheskoy activity (amitriptyline, etc.). In some cases, in the early days of receiving inkazana could experience dry mouth, nausea, fluctuations AD, aetiology. These phenomena are usually at a lower dose.

     Because of the stimulant inkazan contraindicated in azhitirovannyh depression and other conditions involving excitation. It should appoint a drug in acute liver and kidney diseases, during acute alcohol withdrawal symptoms.

     Do not appoint inkazan with other MAO inhibitors and in the first 14 days after their removal.

     Method of issuance : pills to 0,025 g (25 mg) in white in the package for 150 and 250 pieces; 1, 25% solution in ampoules of 2 ml (25 mg) and 1, 25% solution in 10 mL ampoules (125 mg) in a package of 10 vials.

     Storage : List B. In the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines