Human normal immunoglobulin (human normal immunoglobulin)

IMMUNOGLOBULIN CHELOVECHESKY NORMAL (Immunoglobulin human normal)

     Pharmacology : The drugs-immunostimulating effect.

Increases of antibodies in the body. When w / Infusion bioavailability of 100%. Between vnesosudistym space plasma and place of the drug, with the balance achieved in approximately 7 days. A person with normal IgG content in the blood serum of biological half-time averages 21 days, while in patients with primary or hypo-agammaglobulinemiey 32 days. Contains a wide range opsoniziruyuschih and neutralizing antibodies against bacteria, viruses and other pathogens. For patients with primary or secondary immunodeficiency syndrome, ensure the completion of missing class IgG antibody, which reduces the risk of infection.

     Application : substitution therapy to prevent infection with primary immunodeficiency syndromes : agammaglobulinemii, conventional variabelnyh immunodeficiency associated with a gipogammaglobulinemiey or; Deficit IgG subclasses, substitution therapy to prevent infection with secondary immunodeficiency syndrome caused by chronic lymphoblastic AIDS in children or transplants bone marrow, idiopathic trombotsitopenicheskaya Purple, Kawasaki syndrome (in addition to treatment with drugs acetylsalicylic acid), heavy bacterial, including sepsis (in combination with antibiotics) and viral infection, preventing infections in premature babies with low birth weight (less than 1,500 grams) , Giyena-Barre syndrome and chronic inflammation demieliniziruyuschaya polineyropatiya, Autoimmune neutropenia, head krasnokletochnaya aplaziya blood, immune thrombocytopenia origin, including posttransfuzionnaya Purple, izoimmunnaya thrombocytopenia newborns, haemophilia, caused by the formation of antibodies to the exit, myasthenia gravis, prevention and treatment of infections with therapy cytostatica and immunosuppressants, preventing normal fetus.

     Contraindications : Giperchuvstvitelnost to human immunoglobulins, especially in patients with IgA deficiency through education to the antibody.

     Side effects : Headache, nausea, dizziness, vomiting, abdominal pain, diarrhoea, arterial hypo - or hypertension, tachycardia, cyanosis, dyspnoea, or sdavleniya feeling pain in the chest, allergic reactions; Rarely, severe hypotension, collapse, loss of consciousness , hyperthermia, vomiting, increased sweating, a feeling of tiredness, weakness, pain in his back, mialgiya, vomiting, applying heat or cold feeling.

     Interaction : Can reduce the effectiveness of booster : live virus vaccine for parenteral application should not be used for at least 30 days after the introduction of immunoglobulin.

     Dosing and Administration : W / in, drip. Batch Mode set individually, depending on the evidence, the seriousness of the disease of the immune system, individual endurance. When symptoms of primary and secondary immunodeficiency single dose of 0,2-0,8 g / kg (average, 0.4 g / kg); Enter at intervals of 2-4 weeks (to maintain minimum levels of IgG in plasma, constituting 5 g / L). To prevent infections in patients who have a bone marrow Allotransplantation, 0.5 g / kg once for 7 days before the transplant, and then one day a week for the first 3 months after transplantation, and 1 per month for the next nine months. In idiopathic trombotsitopenicheskoy glory - 0.4 g / kg 5 days; In the future (if necessary) to 0.4 g / kg at intervals of 1-4 weeks to maintain the normal level of platelets. When Kawasaki syndrome - 0,6-2 g / kg in a number of techniques for 2-4 days. In severe bacterial infections (including sepsis) and viral infection-0,4-1 g / kg daily for a period of 1-4 days. To prevent infections in premature babies with low birth weight-0,5-1 g / kg at intervals of 1-2 weeks. Guillain Barre syndrome in chronic inflammatory and neuropathic demieliniziruyuschey - 0.4 g / kg for 5 days; If necessary, five-day treatments are repeated at intervals of 4 weeks.

     Precautions : Most of the side effects associated with a high rate of infusion and can be kupirovano stopped or slowed Infusion. In the event of a severe side effects of the introduction should stop (may show adrenaline, protivogistaminnye funds plazmozameniteli and corticosteroids). If the kidney function to monitor patients during treatment (control-creatinine within 3 days after injection). Since the introduction of increased immunoglobulin (passive) antibody in the blood that can lead to erroneous interpretation of the results of serological studies.

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